VSTM4 - V-set and transmembrane domain containing 4 Gene

Also Known as C10orf72

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 196740

About VSTM4

This gene has 3 transcripts (splice variants), 264 orthologues and 5 paralogues. Broad expression in adrenal (RPKM 18.4), ovary (RPKM 14.7) and 19 other tissues.

Summary

Predicted to act upstream of or within several processes, including endothelial cell migration; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

VSTM4 Products (2)

mRNA Protein Name
NM_001031746.5 NP_001026916.2 V-set and transmembrane domain-containing protein 4 isoform 1 precursor
NM_144984.4 NP_659421.1 V-set and transmembrane domain-containing protein 4 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSTM4 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (27 - 130)

  • 0
  • 100
  • 200
  • 300
  • 320 a.a.
Protein Preferred Names Protein Names

V-set and transmembrane domain-containing protein 4

VSTM4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VSTM4 Q8IW00 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
VSTM4 Q8IW00 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
VSTM4 Q8IW00 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
VSTM4 Q8IW00 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
VSTM4 Q8IW00 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
VSTM4 Q8IW00 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
VSTM4 Q8IW00 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
VSTM4 Q8IW00 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
VSTM4 Q8IW00 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra
VSTM4 Q8IW00 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Intra
VSTM4 Q8IW00 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
VSTM4 Q8IW00 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
VSTM4 Q8IW00 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
VSTM4 Q8IW00 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
VSTM4 Q8IW00 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
VSTM4 Q8IW00 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
VSTM4 Q8IW00 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
VSTM4 Q8IW00 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
VSTM4 Q8IW00 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
VSTM4 Q8IW00 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Jackson-Weiss Syndrome

  • JWS

  • Craniosynostosis, Midfacial Hypoplasia, And Foot Abnormalities

  • Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities Syndrome

  • Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15717 VSTM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22916 Vstm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29430 Vstm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris VSTM4 VGNC VGNC:53017
Mus musculus VSTM4 MGD MGI:2444633
Rattus norvegicus VSTM4 RGD RGD:1310423
Felis catus VSTM4 VGNC VGNC:66984
Macaca mulatta VSTM4 VGNC VGNC:79615
Bos taurus VSTM4 VGNC VGNC:54511
Others VSTM4 NCBI