2. Gene
  3. PTPN5 - protein tyrosine phosphatase non-receptor type 5 Gene

PTPN5 - protein tyrosine phosphatase non-receptor type 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as STEP; STEP61; PTPSTEP

Gene ID: 84867 | Gene type: protein coding

About PTPN5

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,727,928-18,792,721 (from NCBI)

This gene has 6 transcripts (splice variants), 202 orthologues and 35 paralogues. Biased expression in brain (RPKM 11.0), testis (RPKM 0.9) and 1 other tissue.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be integral component of membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

PTPN5 Products(6)

mRNA Protein Name
NM_001039970.2 NP_001035059.1 tyrosine-protein phosphatase non-receptor type 5 isoform b
NM_001278236.1 NP_001265165.1 tyrosine-protein phosphatase non-receptor type 5 isoform b
NM_001278238.2 NP_001265167.1 tyrosine-protein phosphatase non-receptor type 5 isoform c
NM_001278239.2 NP_001265168.1 tyrosine-protein phosphatase non-receptor type 5 isoform d
NM_006906.2 NP_008837.1 tyrosine-protein phosphatase non-receptor type 5 isoform a
NM_032781.4 NP_116170.3 tyrosine-protein phosphatase non-receptor type 5 isoform a

PTPN5 Protein Structure

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (324 - 552)

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  • 500
  • 565 a.a.
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 5

neural-specific protein-tyrosine phosphatase

Related Diseases

Diseases Alias
Viral Gastritis
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Phencyclidine Abuse

Pcp Abuse
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141800 MurA-IN-1 Inhibitor 96.93% Unkown
HY-RS11428 PTPN5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PTPN5 RGD RGD:3448
Macaca mulatta PTPN5 VGNC VGNC:76606
Canis familiaris PTPN5 VGNC VGNC:45178
Felis catus PTPN5 VGNC VGNC:69165
Mus musculus PTPN5 MGD MGI:97807
Bos taurus PTPN5 VGNC VGNC:33540