RNF146 - ring finger protein 146 Gene

Homo sapiens

Gene ID: 81847 | Gene type: protein coding

About RNF146

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,266,682-127,288,562 (from NCBI)

This gene has 13 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in fat (RPKM 18.0), lung (RPKM 11.1) and 25 other tissues.

Summary

Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF146 Products(10)

mRNA	Protein	Name
NM_001242844.2	NP_001229773.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242845.2	NP_001229774.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242846.2	NP_001229775.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242847.2	NP_001229776.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242848.2	NP_001229777.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242849.2	NP_001229778.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242850.2	NP_001229779.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242851.1	NP_001229780.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242852.2	NP_001229781.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_030963.4	NP_112225.2	E3 ubiquitin-protein ligase RNF146 isoform a

RNF146 Protein Structure

zf-C3HC4

WWE

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF146

RING-type E3 ubiquitin transferase RNF146

Related Diseases

Diseases

Alias

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162175	TAMRA-isoADPr		/	Unkown
HY-RS12056	RNF146 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF146	RGD	RGD:1306482
Canis familiaris	RNF146	VGNC	VGNC:45638
Mus musculus	RNF146	MGD	MGI:1915281
Felis catus	RNF146	VGNC	VGNC:64675
Macaca mulatta	RNF146	VGNC	VGNC:76798
Others	RNF146	NCBI

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