VAMP1 - vesicle associated membrane protein 1 Gene

Homo sapiens

Also known as SYB1; CMS25; SPAX1; VAMP-1

Gene ID: 6843 | Gene type: protein coding

About VAMP1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,462,237-6,470,677 (from NCBI)

This gene has 8 transcripts (splice variants), 126 orthologues, 10 paralogues and is associated with 4 phenotypes. Broad expression in bone marrow (RPKM 21.7), lymph node (RPKM 20.9) and 23 other tissues.

Summary

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

VAMP1 Products(4)

mRNA	Protein	Name
NM_001297438.2	NP_001284367.1	vesicle-associated membrane protein 1 isoform 4
NM_014231.5	NP_055046.1	vesicle-associated membrane protein 1 isoform 1
NM_016830.4	NP_058439.1	vesicle-associated membrane protein 1 isoform 3
NM_199245.3	NP_954740.1	vesicle-associated membrane protein 1 isoform 2

VAMP1 Protein Structure

Synaptobrevin

0
100
118 a.a.

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 1

vesicle-associated membrane protein 1 (synaptobrevin 1)

Related Diseases

Diseases

Alias

Spastic Ataxia 1, Autosomal Dominant

SPAX1	Ataxia, Spastic, 1, Autosomal Dominant
Autosomal Dominant Spastic Ataxia Type 1	Ataxia, Spastic, Type 1, Autosomal Dominant

Myasthenic Syndrome, Congenital, 25, Presynaptic

CMS25

Myasthenic Syndrome, Congenital, 25

Spastic Ataxia 1

Congenital Myasthenic Syndrome

Congenital Myasthenia	Congenital Myasthenic Syndromes
Cms	Myasthenic Syndromes, Congenital
Myasthenic Syndromes Congenital	Myasthenic Syndrome, Congenital
Congenital Myasthenic Syndrome Ib	Congenital And Developmental Myasthenia
Developmental Myasthenia

Presynaptic Congenital Myasthenic Syndromes

Presynaptic Congenital Myasthenic Syndrome

Congenital Myasthenic Syndromes, Presynaptic

Autosomal Dominant Spastic Ataxia

Ad-Spax

Spastic Ataxia

Spax	Ataxia, Spastic

Foodborne Botulism

Botulism	Botulism Poisoning
Intoxication With Clostridium Botulinum Toxin	Wound Botulism
Food Poisoning Due To Clostridium Botulinum	Infection Due To Clostridium Botulinum
Infant Botulism	Intoxication Botulism
Botulism, Infantile	Clostridium Botulinum Poisoning
Botulism Nos

Infant Botulism

Infant Intestinal Botulism	Infant Intestinal Toxemia Botulism
Infant Intestinal Toxin-Mediated Botulism	Infantile Botulism
Botulism, Infantile

Intermittent Squint

Intermittent Heterotropia

Intermittent Tropia

Wound Botulism

Cutaneous Infectious Botulism	Cutaneous Toxin-Mediated Botulism
Inoculation Botulism	Skin Infectious Botulism
Skin Toxin-Mediated Botulism

Tetanus Neonatorum

Neonatal Tetanus	NNT
Trismus Neonatorum	Newborn Trismus

Spinocerebellar Ataxia, Autosomal Recessive 23

SCAR23	Autosomal Recessive Spinocerebellar Ataxia 23
Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Tud Deficiency	Autosomal Recessive Cerebellar Ataxia - Epilepsy - Intellectual Disability Syndrome Due To Tud Deficiency
Spinocerebellar Ataxia Autosomal Recessive Type 23	Spinocerebellar Ataxia, Autosomal Recessive, 23
Ataxia, Spinocerebellar, Autosomal Recessive, Type 23

Chief Cell Adenoma

Chief Cell Adenoma Of Parathyroid Gland

Severe Congenital Neutropenia 5

Congenital Neutropenia-Myelofibrosis-Nephromegaly Syndrome	Congenital Neutropenia-Bone Marrow Fibrosis-Nephromegaly Syndrome
Vps45 Deficiency	Scn5

Neuromuscular Junction Disease

Neuromuscular Junction Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15593	VAMP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VAMP1	RGD	RGD:3948
Canis familiaris	VAMP1	VGNC	VGNC:54386
Mus musculus	VAMP1	MGD	MGI:1313276
Bos taurus	VAMP1	VGNC	VGNC:36756

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