VAMP1 - vesicle associated membrane protein 1 Gene

Also Known as SYB1; CMS25; SPAX1; VAMP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6843

About VAMP1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,462,237-6,470,677 (from NCBI)

This gene has 8 transcripts (splice variants), 126 orthologues, 10 paralogues and is associated with 4 phenotypes. Broad expression in bone marrow (RPKM 21.7), lymph node (RPKM 20.9) and 23 other tissues.

Summary

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

VAMP1 Products (4)

mRNA	Protein	Name
NM_001297438.2	NP_001284367.1	vesicle-associated membrane protein 1 isoform 4
NM_014231.5	NP_055046.1	vesicle-associated membrane protein 1 isoform 1
NM_016830.4	NP_058439.1	vesicle-associated membrane protein 1 isoform 3
NM_199245.3	NP_954740.1	vesicle-associated membrane protein 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9920726	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in azurophil granule membrane	IDA IDA: Inferred from direct assay	11391393	GOA
NOT located in cytosol	IDA IDA: Inferred from direct assay	11391393	GOA
located in specific granule membrane	IDA IDA: Inferred from direct assay	11391393	GOA
located in tertiary granule membrane	IDA IDA: Inferred from direct assay	11391393	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP1 Protein Structure

Synaptobrevin

0
100
118 a.a.

Protein Preferred Names	Protein Names
vesicle-associated membrane protein 1	vesicle-associated membrane protein 1 (synaptobrevin 1)

VAMP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VAMP1	P23763	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	25416956
Intra	VAMP1	P23763	SNAP29	Homo sapiens	O95721	Validated Y2H	25416956
Intra	VAMP1	P23763	STX4	Homo sapiens	Q12846	Validated Y2H	25416956
Intra	VAMP1	P23763	STX4	Homo sapiens	Q12846	Y2H Array	25416956
Intra	VAMP1	P23763	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	25416956
Intra	VAMP1	P23763	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
Intra	VAMP1	P23763	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

VAMP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82311	VAMP1 Antibody (YA2056)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spastic Ataxia 1, Autosomal Dominant	SPAX1 Ataxia, Spastic, 1, Autosomal Dominant Autosomal Dominant Spastic Ataxia Type 1 Ataxia, Spastic, Type 1, Autosomal Dominant
Myasthenic Syndrome, Congenital, 25, Presynaptic	CMS25 Myasthenic Syndrome, Congenital, 25
Spastic Ataxia 1
Congenital Myasthenic Syndrome	Congenital Myasthenia Congenital Myasthenic Syndromes Cms Myasthenic Syndromes, Congenital Myasthenic Syndromes Congenital Myasthenic Syndrome, Congenital Congenital Myasthenic Syndrome Ib Congenital And Developmental Myasthenia Developmental Myasthenia
Presynaptic Congenital Myasthenic Syndromes	Presynaptic Congenital Myasthenic Syndrome Congenital Myasthenic Syndromes, Presynaptic
Autosomal Dominant Spastic Ataxia	Ad-Spax
Spastic Ataxia	Spax Ataxia, Spastic
Foodborne Botulism	Botulism Botulism Poisoning Intoxication With Clostridium Botulinum Toxin Wound Botulism Food Poisoning Due To Clostridium Botulinum Infection Due To Clostridium Botulinum Infant Botulism Intoxication Botulism Botulism, Infantile Clostridium Botulinum Poisoning Botulism Nos
Infant Botulism	Infant Intestinal Botulism Infant Intestinal Toxemia Botulism Infant Intestinal Toxin-Mediated Botulism Infantile Botulism Botulism, Infantile
Intermittent Squint	Intermittent Heterotropia Intermittent Tropia
Wound Botulism	Cutaneous Infectious Botulism Cutaneous Toxin-Mediated Botulism Inoculation Botulism Skin Infectious Botulism Skin Toxin-Mediated Botulism
Tetanus Neonatorum	Neonatal Tetanus NNT Trismus Neonatorum Newborn Trismus
Spinocerebellar Ataxia, Autosomal Recessive 23	SCAR23 Autosomal Recessive Spinocerebellar Ataxia 23 Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Tud Deficiency Autosomal Recessive Cerebellar Ataxia - Epilepsy - Intellectual Disability Syndrome Due To Tud Deficiency Spinocerebellar Ataxia Autosomal Recessive Type 23 Spinocerebellar Ataxia, Autosomal Recessive, 23 Ataxia, Spinocerebellar, Autosomal Recessive, Type 23
Chief Cell Adenoma	Chief Cell Adenoma Of Parathyroid Gland
Severe Congenital Neutropenia 5	Congenital Neutropenia-Myelofibrosis-Nephromegaly Syndrome Congenital Neutropenia-Bone Marrow Fibrosis-Nephromegaly Syndrome Vps45 Deficiency Scn5
Neuromuscular Junction Disease	Neuromuscular Junction Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10809	VAMP	Inhibitor	98.13%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15593	VAMP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VAMP1	RGD	RGD:3948
Canis familiaris	VAMP1	VGNC	VGNC:54386
Mus musculus	VAMP1	MGD	MGI:1313276
Bos taurus	VAMP1	VGNC	VGNC:36756
Others	VAMP1	NCBI