1. Immunology/Inflammation
    Cell Cycle/DNA Damage
    Apoptosis
  2. COX
    PPAR
    Apoptosis
  3. SC-236

SC-236 

Cat. No.: HY-W010983
Handling Instructions

SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 supresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model.

For research use only. We do not sell to patients.

SC-236 Chemical Structure

SC-236 Chemical Structure

CAS No. : 170569-86-5

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5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
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25 mg USD 250 In-stock
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50 mg USD 450 In-stock
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100 mg USD 750 In-stock
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Description

SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 supresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model[1][2][3][4][5].

IC50 & Target[5]

COX-2

10 nM (IC50)

COX-1

17.8 μM (IC50)

In Vitro

SC-236 (15 μM, 30 min) suppresses the side effects of NSAIDs and prevented inflammation in vECs subjected to ALSS[1].
SC-236 significantly induces PPARγ expression in HSCs and acted as a potent PPARγ agonist in a luciferase-reporter trans-activation assay[2].
SC-236 strongly inhibits, in a time- and concentration-dependent manner, macrophage viability[2].
SC-236, either alone or in combination with 15d-PGJ2, induced a marked pro-apoptotic effect in HSCs in culture[2].
SC-236 mediates antitumor effect by modulation of AP-1-signaling pathway[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: vECs.
Concentration: 15 μM
Incubation Time: 30 min.
Result: Showd significant reduction in COX-2 level and increase in IκBα level, thus preventing ALSS-induced NFκB activation and inflammation in vECs.

Western Blot Analysis[2]

Cell Line: COS 7 cells.
Concentration: 3 and 10 μM.
Incubation Time: 18 h (combined with 15d-PGJ2).
Result: Acted in a concentration-dependent manner as a PPARγ agonist.
In Vivo

SC-236 (6 mg/kg, gavage) exhibits anti-fibrotic properties in CCl4- treated animals[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seventy-six male adult Wistar rats weighing 200-220 g (CCl4-treated)[2].
Dosage: 6 mg/kg.
Administration: Orally, 3 times per week.
Result: A marked induction of COX-2 protein expression was detected by immunohistochemistry in the liver of CCl4-treated rats.
Significantly reduced the degree of liver fibrosis.
Dramatically suppressed α-SMA expression in CCl4-treated rats.
Molecular Weight

401.79

Formula

C₁₆H₁₁ClF₃N₃O₂S

CAS No.

170569-86-5

SMILES

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C(Cl)C=C3)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4889 mL 12.4443 mL 24.8886 mL
5 mM 0.4978 mL 2.4889 mL 4.9777 mL
10 mM 0.2489 mL 1.2444 mL 2.4889 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (6.22 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SC-236SC236SC 236COXPPARApoptosisCyclooxygenasePeroxisome proliferator-activated receptorsLiverfibrosisfibrogenesisgastriccancerTNF-αneuroprotectionischemiaallodyniaInhibitorinhibitorinhibit

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HY-W010983
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