2. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK
  3. Aurora Kinase VEGFR
  4. Tinengotinib

Tinengotinib  (Synonyms: TT 00420)

Cat. No.: HY-145601 Purity: 98.45%
COA Handling Instructions

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Tinengotinib is the modulator of one or more protein kinases such as Aurora kinase and VEGFR kinase. Tinengotinib has the potential for the research of these kinase abnormalities diseases mediated, especially cancer-related diseases (extracted from patent WO2018108079A1).

For research use only. We do not sell to patients.

Tinengotinib Chemical Structure

Tinengotinib Chemical Structure

CAS No. : 2230490-29-4

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 187 In-stock
Solution
10 mM * 1 mL in DMSO USD 187 In-stock
Solid
5 mg USD 170 In-stock
10 mg USD 270 In-stock
25 mg USD 490 In-stock
50 mg USD 750 In-stock
100 mg USD 1140 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Tinengotinib Related Antibodies

Top Publications Citing Use of Products

View All Aurora Kinase Isoform Specific Products:

View All Isoforms
Aurora Kinase Aurora A Aurora B Aurora C

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tinengotinib is the modulator of one or more protein kinases such as Aurora kinase and VEGFR kinase. Tinengotinib has the potential for the research of these kinase abnormalities diseases mediated, especially cancer-related diseases (extracted from patent WO2018108079A1)[1].

IC50 & Target

Aurora and VEGFR[1]
Clinical Trial
Molecular Weight

394.86

Formula

C20H19ClN6O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=C(C2=NC3=C(C)NN=C3NC4=C2C=NC(N5CCOCC5)=C4)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (63.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5325 mL 12.6627 mL 25.3254 mL
5 mM 0.5065 mL 2.5325 mL 5.0651 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.45%

COA (257 KB) HNMR (279 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5325 mL 12.6627 mL 25.3254 mL 63.3136 mL
5 mM 0.5065 mL 2.5325 mL 5.0651 mL 12.6627 mL
10 mM 0.2533 mL 1.2663 mL 2.5325 mL 6.3314 mL
15 mM 0.1688 mL 0.8442 mL 1.6884 mL 4.2209 mL
20 mM 0.1266 mL 0.6331 mL 1.2663 mL 3.1657 mL
25 mM 0.1013 mL 0.5065 mL 1.0130 mL 2.5325 mL
30 mM 0.0844 mL 0.4221 mL 0.8442 mL 2.1105 mL
40 mM 0.0633 mL 0.3166 mL 0.6331 mL 1.5828 mL
50 mM 0.0507 mL 0.2533 mL 0.5065 mL 1.2663 mL
60 mM 0.0422 mL 0.2110 mL 0.4221 mL 1.0552 mL
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Tinengotinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tinengotinib2230490-29-4TT 00420TT00420TT-00420Aurora KinaseVEGFRVascular endothelial growth factor receptorAuroraanti-cancerInhibitorinhibitorinhibit

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