2. MAPK/ERK Pathway Cytoskeleton Metabolic Enzyme/Protease
  3. JNK Cadherin Collagen PAI-1
  4. JNK3-IN-11

JNK3-IN-11 is a selective JNK3 inhibitor with an IC50 of 2.08 nM. JNK3-IN-11 binds to the JNK3 ATP-binding pocket, forming conserved hydrogen bonds with Met149 and a water-mediated hydrogen bond with Lys93. JNK3-IN-11 suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic markers COL1A1 and PAI-1, restores E-cadherin expression, and has protection against podocyte injure. JNK3-IN-11 can be used for the research of chronic kidney disease.

For research use only. We do not sell to patients.

JNK3-IN-11

JNK3-IN-11 Chemical Structure

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JNK3-IN-11 Related Antibodies

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Description

JNK3-IN-11 is a selective JNK3 inhibitor with an IC50 of 2.08 nM. JNK3-IN-11 binds to the JNK3 ATP-binding pocket, forming conserved hydrogen bonds with Met149 and a water-mediated hydrogen bond with Lys93. JNK3-IN-11 suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic markers COL1A1 and PAI-1, restores E-cadherin expression, and has protection against podocyte injure. JNK3-IN-11 can be used for the research of chronic kidney disease[1].

IC50 & Target[1]

Collagen I

 

JNK3

2.08 nM (IC50)

In Vitro

JNK3-IN-11 (Compound 50b) (40 min) potently inhibits recombinant human JNK3 with an IC50 of 2.08 nM and shows meaningful selectivity over JNK1, JNK2, p38α, DYRK1B, and RIPK3[1].
JNK3-IN-11 (5 μM; 24 h) effectively suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic marker (COL1A1, PAI-1) expression, restores E-cadherin levels, and is non-cytotoxic in human podocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3-IN-11 Related Antibodies

Western Blot Analysis[1]

Cell Line: Podocytes
Concentration: 5 μM
Incubation Time: 24 h
Result: Reduced TGF-β1-induced COL1A1, PAI-1 expression.
Increased reduced E-cadherin levels.
Molecular Weight

438.88

Formula

C23H20ClFN4O2
SMILES

OC1=CC2=C(C=C1)C(C3=NC(NC4CCOCC4)=NC=C3)=C(C5=CC=C(F)C(Cl)=C5)N2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNK3-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3-IN-11JNKCadherinCollagenPAI-1c-Jun N-terminal kinasePlasminogen activator inhibitor-1Lys93COL1A1p38αMet149c-JunTGF-β1JNK1JNK3JNK2Inhibitorinhibitorinhibit

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