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Cat. No.: HY-181993

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JNK3-IN-11

JNK3-IN-11 is a selective JNK3 inhibitor with an IC50 of 2.08 nM. JNK3-IN-11 binds to the JNK3 ATP-binding pocket, forming conserved hydrogen bonds with Met149 and a water-mediated hydrogen bond with Lys93. JNK3-IN-11 suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic markers COL1A1 and PAI-1, restores E-cadherin expression, and has protection against podocyte injure. JNK3-IN-11 can be used for the research of chronic kidney disease.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₀ClFN₄O₂
Molecular Weight:438.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JNK3-IN-11 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Collagen I

JNK3

2.08 nM (IC₅₀)

All JNK Isoforms :

In Vitro

JNK3-IN-11 (Compound 50b) (40 min) potently inhibits recombinant human JNK3 with an IC₅₀ of 2.08 nM and shows meaningful selectivity over JNK1, JNK2, p38α, DYRK1B, and RIPK3^[1].
JNK3-IN-11 (5 μM; 24 h) effectively suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic marker (COL1A1, PAI-1) expression, restores E-cadherin levels, and is non-cytotoxic in human podocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Podocytes
Concentration:

5 μM
Incubation Time:

24 h
Result:

Reduced TGF-β1-induced COL1A1, PAI-1 expression.
Increased reduced E-cadherin levels.

Chemical Information

Molecular Weight 438.88
Formula C₂₃H₂₀ClFN₄O₂
SMILES

OC1=CC2=C(C=C1)C(C3=NC(NC4CCOCC4)=NC=C3)=C(C5=CC=C(F)C(Cl)=C5)N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lim CH, et al. Design and optimization of potent, selective, and peripherally acting JNK3 inhibitors for chronic kidney disease. Eur J Med Chem. Published online February 19, 2026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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