JNK3-IN-11
JNK3-IN-11 is a selective JNK3 inhibitor with an IC50 of 2.08 nM. JNK3-IN-11 binds to the JNK3 ATP-binding pocket, forming conserved hydrogen bonds with Met149 and a water-mediated hydrogen bond with Lys93. JNK3-IN-11 suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic markers COL1A1 and PAI-1, restores E-cadherin expression, and has protection against podocyte injure. JNK3-IN-11 can be used for the research of chronic kidney disease.
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- Formule: C23H20ClFN4O2
- Masse moléculaire:438.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Collagen I |
JNK3 2.08 nM (IC50) |
In Vitro
JNK3-IN-11 (Compound 50b) (40 min) potently inhibits recombinant human JNK3 with an IC50 of 2.08 nM and shows meaningful selectivity over JNK1, JNK2, p38α, DYRK1B, and RIPK3[1].
JNK3-IN-11 (5 μM; 24 h) effectively suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic marker (COL1A1, PAI-1) expression, restores E-cadherin levels, and is non-cytotoxic in human podocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Podocytes
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Concentration:5 μM
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Incubation Time:24 h
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Result:Reduced TGF-β1-induced COL1A1, PAI-1 expression.
Increased reduced E-cadherin levels.
Chemical Information
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Masse moléculaire 438.88
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Formule C23H20ClFN4O2
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SMILES
OC1=CC2=C(C=C1)C(C3=NC(NC4CCOCC4)=NC=C3)=C(C5=CC=C(F)C(Cl)=C5)N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK3-IN-11 Related Classifications
HY-181993 Related Classifications
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