2. MAPK/ERK Pathway
  3. JNK
  4. AS601245

AS601245 

Cat. No.: HY-11010 Purity: 98.70%
COA Handling Instructions

AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties.

For research use only. We do not sell to patients.

AS601245 Chemical Structure

AS601245 Chemical Structure

CAS No. : 345987-15-7

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Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 210 In-stock
50 mg USD 810 In-stock
100 mg USD 1350 In-stock
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Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

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JNK1 JNK2 JNK3 JNK

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  • References

  • Customer Review

Description

AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties[1][2].

IC50 & Target[1]

hJNK1

150 nM (IC50)

hJNK2

220 nM (IC50)

hJNK3

70 nM (IC50)

In Vitro

AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia[1].
AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HEN mice[1]
Dosage: 0.3, 1, 3, or 10 mg/kg
Administration: P.o.
Result: Decreased the TNF-α release in a dose-dependent manner.
Molecular Weight

372.45

Appearance

Solid

Formula

C20H16N6S
CAS No.
SMILES

N#CC(C1=CC=NC(NCCC2=CC=CN=C2)=N1)C3=NC4=CC=CC=C4S3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (26.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6849 mL 13.4246 mL 26.8492 mL
5 mM 0.5370 mL 2.6849 mL 5.3698 mL
10 mM 0.2685 mL 1.3425 mL 2.6849 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  100% PEG-300

    Solubility: 20 mg/mL (53.70 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  0.5% MC  0.5% Tween-80

    Solubility: 5 mg/mL (13.42 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.68 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.68 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

AS601245345987-15-7AS 601245AS-601245JNKc-Jun N-terminal kinaseTNF-αreleaseanti-InflammatorycoloncancercellsneuroprotectiveInhibitorinhibitorinhibit

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