345987-15-7
Chemical Structure
AS601245
- CAS No.: 345987-15-7
- Formula:C20H16N6S
- Molecular Weight:372.45
IUPAC Name: 2-(benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile
InChIKey: RCYPVQCPYKNSTG-UHFFFAOYSA-N
SMILES: N#CC(C1=CC=NC(NCCC2=CC=CN=C2)=N1)C3=NC4=CC=CC=C4S3
Biological Activity: AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AS601245 | 98.19% | AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties. | ||||||||||||||||||||
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AS601245 (Standard) | ≥98% | AS601245 (Standard) is the analytical standard of AS601245 (HY-11010). This product is intended for research and analytical applications. AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein Kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein Kinases. Neuroprotective properties. | ||||||||||||||||||||
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Similarity Score 0.83
HY-11010AAS601245 TFA -
Similarity Score 0.65
HY-77009JNK-IN-13 -
Similarity Score 0.60
HY-14761Bentamapimod -
Similarity Score 0.50
HY-153538AP-C2 -
Similarity Score 0.47
HY-W0345612,2'-Methylenebisbenzothiazole -
Similarity Score 0.47
HY-1478105-HT7 receptor ligand 1 -
Similarity Score 0.47
HY-153537AP-C1 -
Similarity Score 0.46
HY-153540AP-C4 -
Similarity Score 0.46
HY-118131PKR-IN-C51 -
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