2. MAPK/ERK Pathway
  3. p38 MAPK JNK
  4. HE4-1 leech peptide

HE4-1 leech peptide is a p38 MAPK inhibitor with an additional c-Jun N-terminal kinase (JNK) inhibitory role. HE4-1 leech peptide suppresses macrophage migration, and does not significantly affect macrophage immunological activities including phagocytic ability, lysozyme activity, and expression levels of most inflammatory factors. HE4-1 leech peptide can be used for the research of atherosclerosis.

For research use only. We do not sell to patients.

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HE4-1 leech peptide

HE4-1 leech peptide Chemical Structure

CAS No. : 2531396-44-6

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HE4-1 leech peptide Related Antibodies

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Description

HE4-1 leech peptide is a p38 MAPK inhibitor with an additional c-Jun N-terminal kinase (JNK) inhibitory role. HE4-1 leech peptide suppresses macrophage migration, and does not significantly affect macrophage immunological activities including phagocytic ability, lysozyme activity, and expression levels of most inflammatory factors. HE4-1 leech peptide can be used for the research of atherosclerosis[1].

In Vitro

HE4-1 leech peptide (200-800 μg/mL; 24 h after 2 h LPS pretreatment) inhibits LPS-induced migration of RAW264.7 macrophages through p38 MAPK and JNK signaling pathways, and downregulates transcription of MEKK4 and ASK2[1].
HE4-1 leech peptide (200-800 μg/mL; 24 h after 2 h LPS pretreatment) does not significantly affect phagocytic ability, lysozyme activity, or secretion of IL-1β, IL-6, or IL-12 in RAW264.7 macrophages at concentrations up to 800 μg/mL, but increases TNF-α secretion at 400 and 800 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HE4-1 leech peptide Related Antibodies

Cell Migration Assay[1]

Cell Line: RAW264.7 cells
Concentration: 200-800 μg/mL
Incubation Time: 24 h (after 2 h LPS pretreatment)
Result: Inhibited LPS-induced migration of RAW264.7 cells; reduced LPS-induced macrophage migration by 15.2% at 800 μg/mL.\nInhibited LPS-induced migration of RAW264.7 macrophages by 14.9% at 800 μg/mL, similar to the effect of HE4-1.

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 200-800 μg/mL
Incubation Time: 24 h (after 2 h LPS pretreatment)
Result: Did not alter total JNK or p38 protein levels; significantly inhibited LPS-induced phosphorylation of JNK and p38 at 800 μg/mL.
Molecular Weight

1429.49

Formula

C59H96N16O25
CAS No.
Sequence

Glu-Ala-Gly-Ser-Ala-Lys-Glu-Leu-Glu-Gly-Asp-Pro-Val-Ala-Gly
Sequence Shortening

EAGSAKELEGDPVAG
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Purity & Documentation
References
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HE4-1 leech peptide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HE4-1 leech peptide2531396-44-6p38 MAPKJNKc-Jun N-terminal kinaseLPSMEKK4atherosclerosisp38 mitogen-activated protein kinaseASK2RAW264.7 macrophagesmacrophagesIL-1βIL-6Inhibitorinhibitorinhibit

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