HE4-1 leech peptide
HE4-1 leech peptide is a p38 MAPK inhibitor with an additional c-Jun N-terminal kinase (JNK) inhibitory role. HE4-1 leech peptide suppresses macrophage migration, and does not significantly affect macrophage immunological activities including phagocytic ability, lysozyme activity, and expression levels of most inflammatory factors. HE4-1 leech peptide can be used for the research of atherosclerosis.
For research use only. We do not sell to patients.
- CAS No.: 2531396-44-6
- Formula: C59H96N16O25
- Molecular Weight:1429.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HE4-1 leech peptide (200-800 μg/mL; 24 h after 2 h LPS pretreatment) inhibits LPS-induced migration of RAW264.7 macrophages through p38 MAPK and JNK signaling pathways, and downregulates transcription of MEKK4 and ASK2[1].
HE4-1 leech peptide (200-800 μg/mL; 24 h after 2 h LPS pretreatment) does not significantly affect phagocytic ability, lysozyme activity, or secretion of IL-1β, IL-6, or IL-12 in RAW264.7 macrophages at concentrations up to 800 μg/mL, but increases TNF-α secretion at 400 and 800 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:200-800 μg/mL
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Incubation Time:24 h (after 2 h LPS pretreatment)
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Result:Inhibited LPS-induced migration of RAW264.7 cells; reduced LPS-induced macrophage migration by 15.2% at 800 μg/mL.\nInhibited LPS-induced migration of RAW264.7 macrophages by 14.9% at 800 μg/mL, similar to the effect of HE4-1.
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Cell Line:RAW264.7 cells
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Concentration:200-800 μg/mL
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Incubation Time:24 h (after 2 h LPS pretreatment)
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Result:Did not alter total JNK or p38 protein levels; significantly inhibited LPS-induced phosphorylation of JNK and p38 at 800 μg/mL.
Chemical Information
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CAS No. 2531396-44-6
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Molecular Weight 1429.49
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Formula C59H96N16O25
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Sequence
Glu-Ala-Gly-Ser-Ala-Lys-Glu-Leu-Glu-Gly-Asp-Pro-Val-Ala-Gly
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Sequence Shortening
EAGSAKELEGDPVAG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HE4-1 leech peptide Related Classifications
HY-P11650 Related Classifications
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