JNK-IN-25
JNK-IN-25 is a potent and selective JNK1/2/3 inhibitor with IC50 values of 1.54 (JNK1), 1.99 (JNK2), and 0.75 nM (JNK3), respectively. JNK-IN-25 inhibits phosphorylation of c-Jun in cells via covalently bonding with the conserved cysteine of JNK1/2/3. JNK-IN-25 can be used for research of cancer, inflammatory and neurodegenerative diseases.
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- CAS No.: 1644498-54-3
- Formule: C28H27N7O2
- Masse moléculaire:493.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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JNK1 1.54 nM (IC50) |
JNK2 1.99 nM (IC50) |
JNK3 0.75 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
0.244 μM
Compound: 71
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Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation
Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation
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[PMID: 25415535] |
| HeLa | IC50 |
0.13 μM
Compound: 71
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Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation
Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation
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[PMID: 25415535] |
JNK-IN-25 (compound JNK-IN-7) inhibits c-Jun phosphorylation in Hela and A375 cells with EC50s of 130 nM and 244 nM, respectively[1].
JNK-IN-25 (0-3 μM) inhibits phosphorylation of c-Jun, but not MSK1 or p38 in Anisomycin (HY-18982)-stimulated HEK293-ILR1 cells in a dose-dependent manner[1].
JNK-IN-25 covalently binds to the conserved cysteine residues (Cys-154 in JNK3 and Cys116 in JNK1/2) to exert its cellular effects[1].
JNK-IN-25 (1 μM) demonstrates goof Kinase selectivity against a panel of 442 distinct kinases[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1644498-54-3
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Masse moléculaire 493.56
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Formule C28H27N7O2
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SMILES
O=C(C1=CC(NC(/C=C/CN(C)C)=O)=CC=C1)NC(C=C2)=CC=C2NC3=NC=CC(C4=CN=CC=C4)=N3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK-IN-25 Related Classifications
HY-178692 Related Classifications
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