JNK-IN-25 

JNK-IN-25 is a potent and selective JNK1/2/3 inhibitor with IC₅₀ values of 1.54 (JNK1), 1.99 (JNK2), and 0.75 nM (JNK3), respectively. JNK-IN-25 inhibits phosphorylation of c-Jun in cells via covalently bonding with the conserved cysteine of JNK1/2/3. JNK-IN-25 can be used for research of cancer, inflammatory and neurodegenerative diseases^[1].

JNK-IN-25 (compound JNK-IN-7) inhibits c-Jun phosphorylation in Hela and A375 cells with EC₅₀s of 130 nM and 244 nM, respectively^[1].
JNK-IN-25 (0-3 μM) inhibits phosphorylation of c-Jun, but not MSK1 or p38 in Anisomycin (HY-18982)-stimulated HEK293-ILR1 cells in a dose-dependent manner^[1].
JNK-IN-25 covalently binds to the conserved cysteine residues (Cys-154 in JNK3 and Cys116 in JNK1/2) to exert its cellular effects^[1].
JNK-IN-25 (1 μM) demonstrates goof Kinase selectivity against a panel of 442 distinct kinases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

493.56

C₂₈H₂₇N₇O₂

1644498-54-3

O=C(C1=CC(NC(/C=C/CN(C)C)=O)=CC=C1)NC(C=C2)=CC=C2NC3=NC=CC(C4=CN=CC=C4)=N3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang T, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012;19(1):140-154.  [Content Brief]