2. MAPK/ERK Pathway
  3. JNK
  4. J30-8

J30-8 

Cat. No.: HY-125838 Purity: 99.90%
COA Handling Instructions

J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases.

For research use only. We do not sell to patients.

J30-8 Chemical Structure

J30-8 Chemical Structure

CAS No. : 2366255-71-0

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Based on 1 publication(s) in Google Scholar

J30-8 Related Antibodies

Top Publications Citing Use of Products

View All JNK Isoform Specific Products:

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JNK1 JNK2 JNK3 JNK

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Description

J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1].

IC50 & Target[1]

JNK3

40 nM (IC50)

Molecular Weight

373.79

Appearance

Solid

Formula

C17H9ClFN3O2S
CAS No.
SMILES

O=C1N/C(S/C1=C2C(NC3=C\2C=C(F)C=C3)=O)=N/C4=CC=CC=C4Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (17.84 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6753 mL 13.3765 mL 26.7530 mL
5 mM 0.5351 mL 2.6753 mL 5.3506 mL
10 mM 0.2675 mL 1.3376 mL 2.6753 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 0.67 mg/mL (1.79 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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J30-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

J30-82366255-71-0JNKc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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