1. MAPK/ERK Pathway
  2. JNK
  3. J30-8

J30-8 

Cat. No.: HY-125838 Purity: 99.90%
COA Handling Instructions

J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases.

For research use only. We do not sell to patients.

J30-8 Chemical Structure

J30-8 Chemical Structure

CAS No. : 2366255-71-0

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10 mg USD 145 In-stock
25 mg USD 300 In-stock
50 mg USD 485 In-stock
100 mg USD 780 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1].

IC50 & Target[1]

JNK3

40 nM (IC50)

Molecular Weight

373.79

Appearance

Solid

Formula

C17H9ClFN3O2S

CAS No.
SMILES

O=C1N/C(S/C1=C2C(NC3=C\2C=C(F)C=C3)=O)=N/C4=CC=CC=C4Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (17.84 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6753 mL 13.3765 mL 26.7530 mL
5 mM 0.5351 mL 2.6753 mL 5.3506 mL
10 mM 0.2675 mL 1.3376 mL 2.6753 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 0.67 mg/mL (1.79 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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J30-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
J30-8
Cat. No.:
HY-125838
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