2366255-71-0
2366255-71-0
Chemical Structure
J30-8
- CAS No.: 2366255-71-0
- Formula:C17H9ClFN3O2S
- Molecular Weight:373.79
IUPAC Name: (Z)-2-((2-chlorophenyl)imino)-5-((Z)-5-fluoro-2-oxoindolin-3-ylidene)thiazolidin-4-one
InChIKey: HNOFQKYBQYGFNQ-YPKPFQOOSA-N
SMILES: O=C1N/C(S/C1=C2C(NC3=C\2C=C(F)C=C3)=O)=N/C4=CC=CC=C4Cl
Biological Activity: J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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J30-8 | 99.51% | J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases. | ||||||||||||||||||||
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References
- [1]. Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664. [Content Brief]
Keywords
