JNK-1-IN-4
JNK-1-IN-4 (Compound E1) is an inhibitor for JNK, that inhibits JNK-1, JNK-2 and JNK-3 with IC50s of 2.7, 19.0 and 9.0 nM, respectively. JNK-1-IN-4 inhibits the phosphorylation of c-Jun, and reduces the expression of TGF-β1-induced EMT marker proteins, such as fibronectin and α-SMA. JNK-1-IN-4 exhibits good pharmacokinetic characteristics with a bioavailability of 69%. JNK-1-IN-4 exhibits anti-fibrotic effect in Bleomycin (HY-17565)-induced mice idiopathic pulmonary fibrosis models.
For research use only. We do not sell to patients.
- CAS No.: 3047795-60-5
- Formula: C22H25BrN6O3
- Molecular Weight:501.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JNK1 2.7 nM (IC50) |
JNK3 9.0 nM (IC50) |
JNK2 19.0 nM (IC50) |
Chemical Information
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CAS No. 3047795-60-5
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Molecular Weight 501.38
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Formula C22H25BrN6O3
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SMILES
COC1=CC=C(NC2=NC(NC3=CC=C(OCCN(C)C)C=C3C(N)=O)=C(Br)C=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK-1-IN-4 Related Classifications
HY-169177 Related Classifications
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