1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Xaliproden hydrochloride

Xaliproden hydrochloride (Synonyms: SR57746A; SR57746 hydrochloride)

Cat. No.: HY-14604 Purity: 99.05%
Handling Instructions

Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

Xaliproden hydrochloride Chemical Structure

Xaliproden hydrochloride Chemical Structure

CAS No. : 90494-79-4

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Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 580 In-stock
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100 mg USD 890 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases[1][2][3].

IC50 & Target

5-HT1A Receptor

3 nM (IC50)

D2 Receptor

0.1-1 μM (IC50)

Clinical Trial
Molecular Weight

417.89

Formula

C₂₄H₂₃ClF₃N

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (79.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3930 mL 11.9649 mL 23.9297 mL
5 mM 0.4786 mL 2.3930 mL 4.7859 mL
10 mM 0.2393 mL 1.1965 mL 2.3930 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Xaliproden hydrochloride
Cat. No.:
HY-14604
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