1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Xaliproden hydrochloride

Xaliproden hydrochloride (Synonyms: SR57746A; SR57746 hydrochloride)

Cat. No.: HY-14604
Handling Instructions

Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

Xaliproden hydrochloride Chemical Structure

Xaliproden hydrochloride Chemical Structure

CAS No. : 90494-79-4

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Description

Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases[1][2][3].

IC50 & Target[1]

5-HT1A Receptor

3 nM (IC50)

D2 Receptor

0.1-1 μM (IC50)

Molecular Weight

417.89

Formula

C₂₄H₂₃ClF₃N

CAS No.

90494-79-4

SMILES

FC(C1=CC(C2=CCN(CCC3=CC=C4C=CC=CC4=C3)CC2)=CC=C1)(F)F.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

XaliprodenSR57746ASR57746SR 57746SR-577465-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1AdopamineD2anti-depressionanti-anxietyneurodegenerativeInhibitorinhibitorinhibit

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Xaliproden hydrochloride
Cat. No.:
HY-14604
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