2. Others PI3K/Akt/mTOR Neuronal Signaling GPCR/G Protein Protein Tyrosine Kinase/RTK TGF-beta/Smad Epigenetics MAPK/ERK Pathway Stem Cell/Wnt
  3. Reference Standards Akt Dopamine Receptor Trk Receptor 5-HT Receptor PKC JNK ERK
  4. Xaliproden hydrochloride (Standard)

Xaliproden hydrochloride (Standard)  (Synonyms: SR57746A (Standard); SR57746 hydrochloride (Standard))

Cat. No.: HY-14604R Pureza: 98%
Instrucciones de manejo Technical Support

Xaliproden (hydrochloride) (Standard) is the analytical standard of Xaliproden (hydrochloride). This product is intended for research and analytical applications. Xaliproden (SR57746) hydrochloride (SR57746A) is an orally active, highly selective 5-HT1A receptor agonist. Xaliproden hydrochloride activates pertussis toxin-sensitive G protein-coupled signaling cascades, as well as the PKC, ERK1/ERK2, Akt and p21 Ras/MEK-1 pathways. Xaliproden hydrochloride also downregulates the JNK/p66/c-Jun signaling pathway, induces phosphorylation of the shc adaptor protein, regulates extracellular dopamine and 5-HT levels, and induces [35S]GTPγS labeling in rat brain structures rich in 5-HT1A receptors. Xaliproden hydrochloride exerts neurotrophic, neuroprotective, renoprotective, anti-inflammatory, anti-apoptotic, anti-fibrotic and analgesic effects. Xaliproden hydrochloride also enhances NGF-induced neurite outgrowth, promotes motor neuron survival, attenuates renal tubular injury and inhibits chemotherapy-induced mechanical allodynia, without activating or altering NGF-induced TrkA receptor activation. Xaliproden hydrochloride can be used in the research of motor neuron disease, diabetic nephropathy, chemotherapy-induced peripheral neuropathy, amyotrophic lateral sclerosis, Alzheimer's disease, acute tonic nociceptive pain, inflammatory pain, depression and anxiety.

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Xaliproden hydrochloride (Standard)

Xaliproden hydrochloride (Standard) Estructura química

No. CAS : 90494-79-4

Tamaño Precio Stock Cantidad
5 mg Obtener un presupuesto 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
10 mg Obtener un presupuesto 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
25 mg Obtener un presupuesto 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
50 mg Obtener un presupuesto 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
100 mg Obtener un presupuesto 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  
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Information

Xaliproden (hydrochloride) (Standard) is the analytical standard of Xaliproden (hydrochloride). This product is intended for research and analytical applications. Xaliproden (SR57746) hydrochloride (SR57746A) is an orally active, highly selective 5-HT1A receptor agonist. Xaliproden hydrochloride activates pertussis toxin-sensitive G protein-coupled signaling cascades, as well as the PKC, ERK1/ERK2, Akt and p21 Ras/MEK-1 pathways. Xaliproden hydrochloride also downregulates the JNK/p66/c-Jun signaling pathway, induces phosphorylation of the shc adaptor protein, regulates extracellular dopamine and 5-HT levels, and induces [35S]GTPγS labeling in rat brain structures rich in 5-HT1A receptors. Xaliproden hydrochloride exerts neurotrophic, neuroprotective, renoprotective, anti-inflammatory, anti-apoptotic, anti-fibrotic and analgesic effects. Xaliproden hydrochloride also enhances NGF-induced neurite outgrowth, promotes motor neuron survival, attenuates renal tubular injury and inhibits chemotherapy-induced mechanical allodynia, without activating or altering NGF-induced TrkA receptor activation. Xaliproden hydrochloride can be used in the research of motor neuron disease, diabetic nephropathy, chemotherapy-induced peripheral neuropathy, amyotrophic lateral sclerosis, Alzheimer's disease, acute tonic nociceptive pain, inflammatory pain, depression and anxiety.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Peso molecular

417.89

Fòrmula

C24H23ClF3N
No. CAS
SMILES

FC(C1=CC(C2=CCN(CCC3=CC=C4C=CC=CC4=C3)CC2)=CC=C1)(F)F.[H]Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Xaliproden hydrochloride (Standard) Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
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Keywords:

Xaliproden hydrochloride (Standard)90494-79-4SR57746A (Standard) SR57746 hydrochloride (Standard)Reference StandardsAktDopamine ReceptorTrk Receptor5-HT ReceptorPKCJNKERKPKBProtein kinase BTropomyosin related kinase receptor Serotonin Receptor5-hydroxytryptamine ReceptorProtein kinase Cc-Jun N-terminal kinaseExtracellular signal regulated kinases5-HT1AdopamineD2anti-depressionanti-anxietyneurodegenerativeInhibitorinhibitorinhibit

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