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Cat. No.: HY-N19654

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Oxonantenine

Oxonantenine is an isoquinoline alkaloid isolated from the seeds of Nandina domestica that exhibits cytotoxicity against cancer cells. Oxonantenine binds to proteins associated with the MAPK and NF-κB signaling pathways, including JUN, MAPK1, p38, MAPK3, ERK, JNK3, and p65. Oxonantenine is one of the main components of Fangji Huangqi Tang. Oxonantenine can be used in studies related to non-small cell lung cancer and rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 15358-38-0
Formula: C₁₉H₁₃NO₅
Molecular Weight:335.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Oxonantenine Chemical Structure

CAS No.: 15358-38-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target^[2]

JNK3

All NF-κB Isoforms :

All p38 MAPK Isoforms :

All ERK Isoforms :

All JNK Isoforms :

In Vitro

Oxonantenine (8.15 μM; 48 h) potently inhibits the viability of A549 cells with an IC₅₀ of 8.15 μM^[1].
Oxonantenine potently binds to MAPK/NF-κB signaling pathway-related proteins (JUN, MAPK1, p38, MAPK3, ERK, JNK3, p65) with binding energies ranging from -33.39 to -44.61 kcal/mol, indicating stable target interactions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 15358-38-0
Molecular Weight 335.31
Formula C₁₉H₁₃NO₅
SMILES

O=C1C2=NC=CC3=CC(OC)=C(C(C4=C1C=C5OCOC5=C4)=C23)OC
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qin J, et al. Two new isoquinoline alkaloids from the seeds of Nandina domestica. Nat Prod Res. 2021 Oct;35(19):3254-3260. [Content Brief]

[2]. Zhang W, et al. Network Pharmacology-Based Strategy Integrated with Molecular Docking and In Vitro Experimental Validation to Explore the Underlying Mechanism of Decoction in Treating Rheumatoid Arthritis. ACS omega. 2024 Jul 23;9(29):31878-31889. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Oxonantenine

All NF-κB Isoforms

All p38 MAPK Isoforms

All ERK Isoforms

All JNK Isoforms