Two new isoquinoline alkaloids from the seeds of Nandina domestica

  • Nat Prod Res. 2021 Oct;35(19):3254-3260. doi: 10.1080/14786419.2019.1696334.
Juan Qin  1 ,  Sheng-Yuan Zhang  1  2 ,  Yu-Bo Zhang  1  3 ,  Li-Feng Chen  1 ,  Neng-Hua Chen  1 ,  Zhong-Nan Wu  1 ,  Ding Luo  1 ,  Guo-Cai Wang  1 ,  Yao-Lan Li  1
Affiliations
  • 1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China.
  • 2. Medical College, Jiaying University, Meizhou, China.
  • 3. Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, China.
PMID: 31872787 DOI: 10.1080/14786419.2019.1696334
Abstract

Two new Isoquinoline Alkaloids, 6 R,6aS-N-nantenine Nβ-oxide (1), 6S,6aS-N-nantenine Nα-oxide (2), along with nine known Alkaloids, nantenine (3), oxonantenine (4), protopine (5), nornantenine (6), N-methyl-laurotetanine (7), isocorydine (8), O-methyflavinantine (9), N-methyl-2,3,6-trimethoxymorphinan-dien-7-one Nβ-oxide (10) and (+)-10-O-methylhernovine Nβ-oxide (11) were isolated from the seeds of Nandina domestica. Their structures were elucidated by extensive analyses of spectroscopic data (IR, UV, HRESIMS, 1 D and 2 D NMR), ECD calculation and comparison with the related literatures. In addition, the cytotoxicity against A549 cells of these Alkaloids was determined by the MTT assay.

Keywords
Nandina domestica; cytotoxicity; isoquinoline alkaloid.
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