15358-38-0
Chemical Structure
Oxonantenine
- No. CAS: 15358-38-0
- Formula:C19H13NO5
- Molecular Weight:335.31
InChIKey: NFDVJYPMLVMXRR-UHFFFAOYSA-N
SMILES: O=C1C2=NC=CC3=CC(OC)=C(C(C4=C1C=C5OCOC5=C4)=C23)OC
Biological Activity: Oxonantenine is an isoquinoline alkaloid isolated from the seeds of Nandina domestica that exhibits cytotoxicity against cancer cells. Oxonantenine binds to proteins associated with the MAPK and NF-κB signaling pathways, including JUN, MAPK1, p38, MAPK3, ERK, JNK3, and p65. Oxonantenine is one of the main components of Fangji Huangqi Tang. Oxonantenine can be used in studies related to non-small cell lung cancer and rheumatoid arthritis[1][2].
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Oxonantenine | Oxonantenine is an isoquinoline alkaloid isolated from the seeds of Nandina domestica that exhibits cytotoxicity against cancer cells. Oxonantenine binds to proteins associated with the MAPK and NF-κB signaling pathways, including JUN, MAPK1, p38, MAPK3, ERK, JNK3, and p65. Oxonantenine is one of the main components of Fangji Huangqi Tang. Oxonantenine can be used in studies related to non-small cell lung cancer and rheumatoid arthritis. | |||||||||||||||||||||
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- [1]. Qin J, et al. Two new isoquinoline alkaloids from the seeds of Nandina domestica. Nat Prod Res. 2021 Oct;35(19):3254-3260. [Content Brief]
- [2]. Zhang W, et al. Network Pharmacology-Based Strategy Integrated with Molecular Docking and In Vitro Experimental Validation to Explore the Underlying Mechanism of Decoction in Treating Rheumatoid Arthritis. ACS omega. 2024 Jul 23;9(29):31878-31889. [Content Brief]
Keywords
