1. MAPK/ERK Pathway
    Apoptosis
  2. JNK
    Apoptosis
  3. AEG3482

AEG3482 

Cat. No.: HY-107599
Handling Instructions

AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.

For research use only. We do not sell to patients.

AEG3482 Chemical Structure

AEG3482 Chemical Structure

CAS No. : 63735-71-7

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All JNK Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25[1].

IC50 & Target

JNK[1]

In Vitro

AEG3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ∼20 μM[1].
AEG3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner[1].
AEG3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: PC12 cells
Concentration: 1, 2.5, 5, 10, 20, 40, 80 μM
Incubation Time: 40 hours
Result: Reduced p75NTR- or NRAGE-induced cell death by greater than 90% at the concentration of 40 μM.
Exerted a slight toxic effect in cells infected with the LacZ control at the concentration of 80 μM.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 10, 20, 40 μM
Incubation Time: 30 hours
Result: Attenuated p75NTR- and NRAGE-induced c-Jun phosphorylation and caspase-3 cleavage, and the levels of c-Jun protein.
Molecular Weight

280.33

Formula

C₁₀H₈N₄O₂S₂

CAS No.
SMILES

O=S(C1=NN2C(S1)=NC(C3=CC=CC=C3)=C2)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AEG3482AEG 3482AEG-3482JNKApoptosisc-Jun N-terminal kinaseantiapoptoticJunkinaseheatshockprotein70HSP70HSP90HSF1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AEG3482
Cat. No.:
HY-107599
Quantity:
MCE Japan Authorized Agent: