Search Result

Results for "

antiapoptotic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (33) Autophagy (7) Bacterial (2) Bcl-2 Family (9) Bcr-Abl (1) Biochemical Assay Reagents (1) Calcium Channel (2) Caspase (4) Cytochrome P450 (2) Deubiquitinase (1) Endogenous Metabolite (5) ERK (3) Fatty Acid Synthase (FASN) (2) FLT3 (1) FXR (2) GCGR (1) Glucosidase (1) HBV (1) HDAC (1) Histone Methyltransferase (1) HIV (1) HSP (1) IAP (2) Influenza Virus (1) Interleukin Related (2) Isotope-Labeled Compounds (1) JNK (2) MDM-2/p53 (1) MEK (1) Mitophagy (2) NF-κB (6) P-glycoprotein (1) p38 MAPK (3) PGE synthase (1) Pim (1) Platelet-activating Factor Receptor (PAFR) (1) PPAR (2) Reactive Oxygen Species (7) Ser/Thr Protease (1) TNF Receptor (2) Tyrosinase (3) Virus Protease (2)
By Research Areas:	Cancer (37) Cardiovascular Disease (6) Endocrinology (1) Infection (6) Inflammation/Immunology (21) Metabolic Disease (3) Neurological Disease (17)

By Targets:

Akt (1)

Apoptosis (33)

Autophagy (7)

Bacterial (2)

Bcl-2 Family (9)

Bcr-Abl (1)

Biochemical Assay Reagents (1)

Calcium Channel (2)

Caspase (4)

Cytochrome P450 (2)

Deubiquitinase (1)

Endogenous Metabolite (5)

ERK (3)

Fatty Acid Synthase (FASN) (2)

FLT3 (1)

FXR (2)

GCGR (1)

Glucosidase (1)

HBV (1)

HDAC (1)

Histone Methyltransferase (1)

HIV (1)

HSP (1)

IAP (2)

Influenza Virus (1)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

JNK (2)

MDM-2/p53 (1)

MEK (1)

Mitophagy (2)

NF-κB (6)

P-glycoprotein (1)

p38 MAPK (3)

PGE synthase (1)

Pim (1)

Platelet-activating Factor Receptor (PAFR) (1)

PPAR (2)

Reactive Oxygen Species (7)

Ser/Thr Protease (1)

TNF Receptor (2)

Tyrosinase (3)

Virus Protease (2)

By Research Areas:

Cancer (37)

Cardiovascular Disease (6)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (21)

Metabolic Disease (3)

Neurological Disease (17)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122267A

cis-Clovamide

Apoptosis Inflammation/Immunology

cis-Clovamide, a natural phenolic compound with antioxidant, anti-inflammatory and antiapoptotic activities .

cis-Clovamide	Apoptosis	Inflammation/Immunology
cis-Clovamide, a natural phenolic compound with antioxidant, anti-inflammatory and antiapoptotic activities .

HY-162137

Hepatoprotective agent-1	Apoptosis	Inflammation/Immunology
Hepatoprotective agent-1 (compound 1b) is a hepatoprotective agenrt. Hepatoprotective agent-1 shows anti-inflammatory, *antiapoptotic* and antifibrotic effects .

HY-W027126

Hepatoprotective agent-2	Apoptosis	Metabolic Disease
Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, displays a remarkable hepatoprotective effect. Hepatoprotective agent-2 has *antiapoptotic* activity. Hepatoprotective agent-2 notably prevents the chemically induced elevation of hepatic indicators associated with liver injury .

HY-N7697D

Chitoheptaose heptahydrochloride	Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings .

HY-N9933

Tauro-β-muricholic acid TβMCA	FXR Apoptosis	Metabolic Disease Cancer
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC₅₀ = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-107599

AEG3482	JNK Apoptosis	Neurological Disease
AEG3482 is a potent *antiapoptotic* compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .

HY-142026

Vitisin A (+)-Vitisin A	NF-κB ERK	Inflammation/Immunology
Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots .

HY-15191B

(S)-Sabutoclax (S)-BI-97C1	Bcl-2 Family	Cancer
(S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC₅₀ values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC₅₀ values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer .

HY-N1778

3,4-Dimethoxycinnamic acid O-Methylferulic acid	Reactive Oxygen Species Virus Protease	Infection Cancer
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N1778A

(E)-3,4-Dimethoxycinnamic acid (E)-O-Methylferulic acid	Reactive Oxygen Species Virus Protease	Infection Cancer
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-143230

Custirsen OGX-011	Apoptosis	Cancer
Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

HY-138832

BM-1244 APG-1252-M1	Bcl-2 Family	Cancer
BM-1244 (APG-1252-M1) is a potent Bcl-xL/Bcl-2 inhibitor with K_is of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC₅₀ of 5 nM. (From patent WO2019033119A1) .

HY-160108

Bcl-2-IN-17

Bcl-2 Family Others

Bcl-2-IN-17 is a Bcl2 inhibitor and can be used for the research of diseases associated with Bcl anti-apoptotic protein .

Bcl-2-IN-17	Bcl-2 Family	Others
Bcl-2-IN-17 is a Bcl2 inhibitor and can be used for the research of diseases associated with Bcl anti-apoptotic protein .

HY-N0783

Eupatilin 5+ Cited Publications	PPAR Autophagy	Neurological Disease Inflammation/Immunology Cancer
Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα* agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.*

HY-N0153

Naringin 10+ Cited Publications Naringoside	Cytochrome P450 Autophagy Mitophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities.

HY-12305A

(R)-Q-VD-OPh (R)-QVD-OPH; (R)-Quinoline-Val-Asp-Difluorophenoxymethylketone	Apoptosis	Cancer
(R)-Q-VD-OPh ((R)-QVD-OPH) is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible pan-caspase inhibitor with potent antiapoptotic properties.

HY-N3204

Neoechinulin A	Apoptosis	Neurological Disease
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-10397A

MX1013 2 Publications Verification CV1013; Z-VD-FMK	Caspase	Cancer
MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC₅₀ of 30 nM .

HY-103272

iMAC2	Apoptosis Bacterial	Others
iMAC2 is a potent MAC inhibitor with an IC₅₀ of 28 nM and an LD₅₀ of 15000 nM. iMAC2 shows *anti-apoptotic* effect. iMAC2 blocks cytochrome c release .

HY-P2804

GAPDH, rabbit muscle GADPH; G3PDH; Glyceraldehyde phosphate dehydrogenase	Others	Others
Glyceraldehyde phosphate dehydrogenase (EC 1.2.1.12) is the target of anti-thymocyte and anti-apoptotic agents. Glyceraldehyde phosphate dehydrogenase catalyzes the chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals .

HY-N6850

Calenduloside E 1 Publications Verification	HSP Endogenous Metabolite
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has *anti-apoptotic* potent by targeting heat shock protein 90 (Hsp90) .

HY-N6077

Thalidezine	Others	Cancer
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .

HY-160006

PIM-IN-2	Pim	Cancer
PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC₅₀ = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors .

HY-110073

iMAC2 hydrochloride	Apoptosis	Inflammation/Immunology Cancer
iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC₅₀ of 28 nM and a LD₅₀ of 15000 nM. iMAC2 hydrochloride shows *anti-apoptotic* effect. iMAC2 hydrochloride blocks cytochrome c release .

HY-N6076

Tenuifoliside A	ERK	Neurological Disease
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells .

HY-134616

Ulinastatin 1 Publications Verification Uristatin	Ser/Thr Protease Apoptosis	Neurological Disease Inflammation/Immunology
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects .

HY-161254

ATPase-IN-3	Apoptosis MDM-2/p53	Inflammation/Immunology
ATPase-IN-3 (compound 6) is a ATPase inhibitor. ATPase-IN-3 has Gastroprotective effect in ethanol-induced gastric ulcers by contribution of anti-apoptotic (BCL-2) and tumor suppressor (P53) proteins .

HY-N0783R

Eupatilin (Standard)	PPAR Autophagy	Neurological Disease Inflammation/Immunology Cancer
Eupatilin (Standard) is the analytical standard of Eupatilin. This product is intended for research and analytical applications. Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα* agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.*

HY-13264

Degrasyn 5+ Cited Publications WP1130	Deubiquitinase Bcr-Abl Autophagy Apoptosis	Cancer
Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.

HY-N2037

Higenamine Norcoclaurine; Demethyl-Coclaurine
Higenamine (Norcoclaurine), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine (Norcoclaurine) has anti-apoptotic effects .

HY-10087

Navitoclax Maximum Cited Publications 73 Publications Verification ABT-263	Bcl-2 Family	Cancer
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM .

HY-N0119

Naringin Dihydrochalcone 1 Publications Verification Naringin DC	NF-κB	Cancer
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

HY-P3993

(Gly14)-Humanin (human) 14-Glycine-Humanin (human)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions .

HY-P3993A

(Gly14)-Humanin (human) (acetate) 14-Glycine-Humanin (human) (acetate)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions .

HY-N0153R

Naringin (Standard) Naringoside (Standard)	Endogenous Metabolite Cytochrome P450 Mitophagy Autophagy	Inflammation/Immunology
Naringin (Standard) is the analytical standard of Naringin. This product is intended for research and analytical applications. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities .

HY-149017

Apoptosis inducer 7	Apoptosis	Cancer
Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .

HY-N2638

Ilexsaponin A	Apoptosis	Cardiovascular Disease
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through *anti-apoptotic* pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-152193

ChoKα inhibitor-4	Others	Cancer
ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC₅₀=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression .

HY-N1485

Cycloastragenol 3 Publications Verification Astramembrangenin; Cyclosieversigenin
Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties .

HY-N4005

Isoastilbin	Bacterial Tyrosinase	Infection Neurological Disease
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-N6959

Osmundacetone	Reactive Oxygen Species Apoptosis	Metabolic Disease
Osmundacetone is a natural product isolated from Osmundae Rhizoma, with neuroprotective and anti-apoptotic effects. Osmundacetone also has DPPH scavenging activity and anti-oxidative stress activity. Osmundacetone inhibits MAPK phosphorylation, including JNK, ERK, and p38 kinase. Osmundacetone can be a potential agent for the research of neurodegenerative diseases .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-10930

UNC0321 2 Publications Verification	Histone Methyltransferase GCGR Apoptosis	Cancer
UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a K_i of 63 pM and with assay-dependent IC₅₀ values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC₅₀ values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications .

HY-12305

Q-VD-OPh 40+ Cited Publications QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone	Caspase HIV	Infection Cancer
Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC₅₀ of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.

HY-10087S

Navitoclax-d8	Bcl-2 Family	Cancer
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].

HY-155612

M826	Caspase	Neurological Disease
M826 is a potent, selective and reversible non-peptide caspase-3 inhibitor with an IC₅₀ value of 0.005 μM for enzymatic activity against caspase-3. M826 displays potent anti-apoptotic activity in animal models in vitro and in vivo. M826 can be used for nervous system diseases research .

HY-18628

UMI-77 1 Publications Verification	Bcl-2 Family	Cancer
UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC₅₀=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with K_i of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-N6967

Levomenol (-)-α-Bisabolol	Apoptosis	Neurological Disease Inflammation/Immunology
Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .

HY-101083

BDA-366
BDA-366 is a potent Bcl2 antagonist (K_i = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells .

Cat. No.	Product Name	Target	Research Area

HY-P3993A

(Gly14)-Humanin (human) (acetate) 14-Glycine-Humanin (human) (acetate)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-P1928

Humanin	Bcl-2 Family	Neurological Disease Endocrinology
Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging . Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-P3993

(Gly14)-Humanin (human) 14-Glycine-Humanin (human)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1778

3,4-Dimethoxycinnamic acid O-Methylferulic acid	Infection Classification of Application Fields Securidaca inappendiculata Hassk. Simple Phenylpropanols Source classification Polygalaceae Phenylpropanoids Plants Disease Research Fields	Reactive Oxygen Species Virus Protease
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-122267A

cis-Clovamide	Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis
cis-Clovamide, a natural phenolic compound with antioxidant, anti-inflammatory and antiapoptotic activities .

HY-N7697D

Chitoheptaose heptahydrochloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Reactive Oxygen Species
Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings .

HY-N9933

Tauro-β-muricholic acid TβMCA	Structural Classification Human Gut Microbiota Metabolites Microorganisms Animals Source classification Endogenous metabolite Steroids	FXR Apoptosis
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC₅₀ = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential .

HY-142026

Vitisin A (+)-Vitisin A	Structural Classification Microorganisms Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	NF-κB ERK
Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots .

HY-N1778A

(E)-3,4-Dimethoxycinnamic acid (E)-O-Methylferulic acid	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields	Reactive Oxygen Species Virus Protease
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N0783

Eupatilin 5+ Cited Publications	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Plants Compositae Disease Research Fields Sindora sumatrana Miq. Cancer	PPAR Autophagy
Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα* agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.*

HY-N0153

Naringin Maximum Cited Publications 12 Publications Verification Naringoside	Structural Classification Citrus × aurantium Linnaeus Classification of Application Fields Source classification Rutaceae Plants Endogenous metabolite Flavonoids Leguminosae Flavonones Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Cytochrome P450 Autophagy Mitophagy Endogenous Metabolite
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities.

HY-N3204

Neoechinulin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Indole Alkaloids	Apoptosis
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	HSP Endogenous Metabolite
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has *anti-apoptotic* potent by targeting heat shock protein 90 (Hsp90) .

HY-N6077

Thalidezine	Structural Classification Alkaloids Source classification Nelumbo nucifera Gaertn. Plants Nymphaeaceae Alkaloid Dimers	Others
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .

HY-N6076

Tenuifoliside A	Triterpenes Monophenols Terpenoids Source classification Polygalaceae Phenols Plants Polygala tenuifolia Willd.	ERK
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells .

HY-N0783R

Eupatilin (Standard)	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Source classification Plants Compositae Disease Research Fields Sindora sumatrana Miq. Cancer	PPAR Autophagy
Eupatilin (Standard) is the analytical standard of Eupatilin. This product is intended for research and analytical applications. Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα* agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.*

HY-N0119

Naringin Dihydrochalcone 1 Publications Verification Naringin DC	Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Dihydrochalcones Disease Research Fields Sweeteners Cancer Food Research	NF-κB
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

HY-N0153R

Naringin (Standard) Naringoside (Standard)	Structural Classification Citrus × aurantium Linnaeus Flavonoids Classification of Application Fields Leguminosae Source classification Rutaceae Plants Endogenous metabolite Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Endogenous Metabolite Cytochrome P450 Mitophagy Autophagy
Naringin (Standard) is the analytical standard of Naringin. This product is intended for research and analytical applications. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities .

HY-N2638

Ilexsaponin A	Cardiovascular Disease Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants Disease Research Fields	Apoptosis
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through *anti-apoptotic* pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-N4005

Isoastilbin	Flavanonols Flavonoids other families Source classification Phenols Polyphenols Plants	Bacterial Tyrosinase
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-N6959

Osmundacetone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Source classification Phenols Polyphenols Metabolic Disease Helianthella quinquenervis (Hook.) A.Gray Plants Disease Research Fields	Reactive Oxygen Species Apoptosis
Osmundacetone is a natural product isolated from Osmundae Rhizoma, with neuroprotective and anti-apoptotic effects. Osmundacetone also has DPPH scavenging activity and anti-oxidative stress activity. Osmundacetone inhibits MAPK phosphorylation, including JNK, ERK, and p38 kinase. Osmundacetone can be a potential agent for the research of neurodegenerative diseases .

HY-N6967

Levomenol (-)-α-Bisabolol	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	Apoptosis
Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .

HY-N0403

2,3,4',5-Tetrahydroxystilbene 2-O-β-D-glucoside	Structural Classification Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants	Apoptosis
2,3,4',5-Tetrahydroxystilbene 2-O-β-D-glucoside (TSG) is an active product that can be extracted from Polygonum multiflorum Thunb. TSG has anti-inflammatory, antioxidative, anti-atherosclerotic, *anti-apoptotic*, and free radical scavenging activities, TSG is also indicated to facilitate long-term potentiation and learning and memory in both normal and pathological conditions .

HY-N0619

Mulberroside A 2 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-17473

Embelin 4 Publications Verification Embelic acid; Emberine; NSC 91874	Quinones Classification of Application Fields Source classification Benzene Quinones Plants Embelia laeta (Linn.) Mez Myrsinaceae Disease Research Fields Cancer	IAP NF-κB Apoptosis Autophagy
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC₅₀=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-N0784

Ginkgolide B 3 Publications Verification BN-52021	Structural Classification Classification of Application Fields Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Endogenous metabolite Disease Research Fields Ginkgo biloba Cancer	Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-108635

C16-PAF 5+ Cited Publications PAF (C16)	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	p38 MAPK MEK ERK Endogenous Metabolite
C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability .

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N0058

4,5-Dicaffeoylquinic acid 4 Publications Verification Isochlorogenic acid C	Infection Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Plants Bowdichia virgilioides Compositae Endogenous metabolite Disease Research Fields	HBV Endogenous Metabolite Apoptosis Glucosidase
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-N0408

Picroside II 1 Publications Verification	Infection Structural Classification Iridoids Neurological Disease Classification of Application Fields Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	NF-κB Reactive Oxygen Species Apoptosis Influenza Virus
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways . Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities .

HY-107738

Guggulsterone 5+ Cited Publications Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC₅₀s of 17 and 15 μM for Z- and E-Guggulsterone, respectively .

Cat. No.	Product Name	Chemical Structure

HY-10087S

Navitoclax-d8
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks