Neoechinulin A
Based on 1 Customer Validation
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 51551-29-2
- Formula: C19H21N3O2
- Molecular Weight:323.39
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh7.5.1 | CC50 |
>20 μM
Compound: 7
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Cytotoxicity against human Huh-7.5.1 cells assessed as reduction in cell viability measured at 72 hrs by MTT assay
Cytotoxicity against human Huh-7.5.1 cells assessed as reduction in cell viability measured at 72 hrs by MTT assay
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[PMID: 34967639] |
| MDCK | CC50 |
>200 μM
Compound: 17
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Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay
Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay
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[PMID: 25681711] |
| Vero C1008 | CC50 |
>100 μM
Compound: 7
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Cytotoxicity against African green monkey Vero E6 cells expressing TMPRSS2 assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based confocal microscopic analysis
Cytotoxicity against African green monkey Vero E6 cells expressing TMPRSS2 assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based confocal microscopic analysis
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[PMID: 34967639] |
Neoechinulin A (RAW264.7 macrophages; 3 hours; cells then stimulated with LPS (1 μg/mL) for 18 hours) suppresses PGE2, TNF-α, and IL-1β production in a dose-dependent manner[2].
Neoechinulin A can suppress the production of pro-inflammatory mediators and cytokines including NO, PGE2, TNF-α, and IL-1β. Further, it reduced the expression of iNOS and COX-2 in LPS-stimulated RAW264.7 macrophages by inhibiting the NF-κB and p38 MAPK signaling pathways[2].
Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 51551-29-2
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Appearance Solid
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Molecular Weight 323.39
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Formula C19H21N3O2
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Color White to off-white
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SMILES
C=CC(C)(C)C1=C(C2=CC=CC=C2N1)/C=C3C(N[C@H](C(N/3)=O)C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Humbert M, et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010;5(3):e9430. Published 2010 Mar 4. [Content Brief]
[2]. Kim KS, et al. Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-кB and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules. 2013;18(11):13245-13259. Publish [Content Brief]
[3]. Dewapriya P, et al. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. Neurotoxicology. 2013;35:30-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neoechinulin A Related Classifications
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