1. Apoptosis
  2. Bcl-2 Family
  3. BM-1244

BM-1244 

Cat. No.: HY-138832 Purity: 98.77%
Handling Instructions

BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1).

For research use only. We do not sell to patients.

BM-1244 Chemical Structure

BM-1244 Chemical Structure

CAS No. : 1619923-32-8

Size Price Stock Quantity
1 mg USD 500 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
25 mg USD 3200 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1].

Molecular Weight

1159.79

Formula

C₅₄H₅₉ClF₄N₆O₈S₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (172.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8622 mL 4.3111 mL 8.6223 mL
5 mM 0.1724 mL 0.8622 mL 1.7245 mL
10 mM 0.0862 mL 0.4311 mL 0.8622 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (4.31 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Product Name:
BM-1244
Cat. No.:
HY-138832
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