1. Apoptosis
  2. Bcl-2 Family
    Apoptosis
  3. Pelcitoclax

Pelcitoclax (Synonyms: APG-1252)

Cat. No.: HY-109185
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Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects.

For research use only. We do not sell to patients.

Pelcitoclax Chemical Structure

Pelcitoclax Chemical Structure

CAS No. : 1619923-36-2

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Description

Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects[1].

In Vitro

APG-1252 changes to the reactive metabolite named APG-1252-M1, which has remarkable antitumor effects in acute myeloid leukemia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pelcitoclax (APG-1252; 25-100 mg/kg; i.v.; once a day; for 10days) treatment inhibits xenograft tumor growth more obviously than the other groups[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c athymic nude mice (male, 4-6weeks) injected with N87 cells[1]
Dosage: 25 mg/kg, 50 mg/kg, and 100 mg/kg
Administration: Intravenous injection; once a day; for 10days
Result: Inhibited xenograft tumor growth more obviously than the other groups.
Molecular Weight

1281.85

Formula

C₅₇H₆₆ClF₄N₆O₁₁PS₄

CAS No.
SMILES

O=C(C1CCN(CC[[email protected]@H](NC2=CC=C(S(=O)(NC3=CC=C(N4CCN(C5=CC(F)=CC(C6=C(C7=CC=C(Cl)C=C7)N(C(C)C)C(C)=C6S(=O)(C)=O)=C5)CC4)C=C3)=O)C=C2S(=O)(C(F)(F)F)=O)CSC8=CC=CC=C8)CC1)OCCCP(O)(O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PelcitoclaxAPG-1252APG1252APG 1252Bcl-2 FamilyApoptosisantineoplasticBcl-2Bcl-xlpro-apoptoticInhibitorinhibitorinhibit

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Pelcitoclax
Cat. No.:
HY-109185
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