iMAC2
iMAC2 is a potent MAC inhibitor with an IC50 of 28 nM and an LD50 of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release.
For research use only. We do not sell to patients.
- CAS No.: 335166-36-4
- Formula: C19H20Br2FN3
- Molecular Weight:469.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 28 nM (MAC)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.68 μM
Compound: 13
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In vitro inhibition of Bax regulated release of cytochrome C was determined using liposome channel assay
In vitro inhibition of Bax regulated release of cytochrome C was determined using liposome channel assay
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[PMID: 14521400] |
iMAC2 (5 μM; pre-treatment for 1 hour and then treatment for 12 hours) reduces apoptosis in FL5.12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FL5.12 cells
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Concentration:5 μM
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Incubation Time:Pretreatment 1 h and then treatment with Staurosporine (HY-15141) for 12 hours
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Result:Reduced apoptosis by more than 50%.
Chemical Information
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CAS No. 335166-36-4
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Molecular Weight 469.19
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Formula C19H20Br2FN3
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SMILES
FC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
iMAC2 Related Classifications
HY-103272 Related Classifications
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