1. Apoptosis
    Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. TNF Receptor
    Interleukin Related
    Tyrosinase
  3. cis-Mulberroside A

cis-Mulberroside A (Synonyms: Mulberroside D)

Cat. No.: HY-N0619A
Handling Instructions

cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM.

For research use only. We do not sell to patients.

cis-Mulberroside A Chemical Structure

cis-Mulberroside A Chemical Structure

CAS No. : 166734-06-1

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Description

cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.)[1]. Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects[2]. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM[3].

In Vivo

Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Kun-Ming mice (20±2 g)[4]
Dosage: 5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight
Administration: Orally initiated at 9:00 a.m.
Result: 10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal.
Molecular Weight

568.52

Formula

C₂₆H₃₂O₁₄

CAS No.

166734-06-1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

cis-Mulberroside AMulberroside DTNF ReceptorInterleukin RelatedTyrosinaseTumor Necrosis Factor ReceptorTNFRILInhibitorinhibitorinhibit

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cis-Mulberroside A
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