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Cat. No.: HY-155612

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M826

M826 is a potent, selective and reversible non-peptide caspase-3 inhibitor with an IC₅₀ value of 0.005 μM for enzymatic activity against caspase-3. M826 displays potent anti-apoptotic activity in animal models in vitro and in vivo. M826 can be used for nervous system diseases research.

For research use only. We do not sell to patients.

CAS No.: 321437-16-5
Formula: C₂₈H₄₅N₇O₆
Molecular Weight:575.70

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

M826 Chemical Structure

CAS No.: 321437-16-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NT2	EC₅₀	21 nM Compound: M826	Inhibition of camptothecin induced apoptosis in human NT2 cells incubated for 5 hrs in presence of camptothecin by ELISA method Inhibition of camptothecin induced apoptosis in human NT2 cells incubated for 5 hrs in presence of camptothecin by ELISA method	[PMID: 33569941]

In Vitro

M826 (different concentrations, 20 h) inhibits apoptosis in NT2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

M826 (30 nmol for intracerebroventricular (ICV)-injected) blocks caspase-3 activation and cleavage of its substrates in neonatal H-I rat model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 321437-16-5
Appearance Solid
Molecular Weight 575.70
Formula C₂₈H₄₅N₇O₆
Color Colorless to off-white
SMILES

O=C(O)CC(NC([C@@H](N1C(C(NCC2=NON=C2C)=NC(C(C)(C)C)=C1)=O)CC)=O)C(CN(C)CCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Han BH, et al. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury. J Biol Chem. 2002 Aug 16;277(33):30128-36.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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M826

All Caspase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

M826 Related Classifications

HY-155612 Related Classifications