(Gly14)-Humanin (human)
Based on 1 Customer Validation
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.
For research use only. We do not sell to patients.
- Purity: 95.39%
- CAS No.: 330936-70-4
- Formula: C118H202N34O31S2
- Molecular Weight:2657.21
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(Gly14)-Humanin (human) (0.1-10 μM; 72 hours) significantly increases cell viability, reduced nuclear fluorescence of HUVECs, the levels of cleaved PARP, ROS formation and the ratio of bax/bcl-2 compared with treatment with high glucose (HG) for 72h. And reduces mRNA level of bax and increases mRNA level of bcl-2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human umbilical vein endothelial cells (HUVECs)
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Concentration:100 nM, 1 μM and 10 μM
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Incubation Time:Pretreatment 3 hours and then treated with 72 hours
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Result:Significantly increased cell viability.
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Cell Line:Human umbilical vein endothelial cells (HUVECs)
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Concentration:1 μM
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Incubation Time:Pretreatment 3 hours and then treated with 72 hours
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Result:Reduced the ratio of bax/bcl-2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)[2]
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Dosage:0.1 μg/5 μL
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Administration:Intracerebroventricularly (i.c.v.); once
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Result:Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.
Chemical Information
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CAS No. 330936-70-4
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Appearance Solid
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Molecular Weight 2657.21
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Formula C118H202N34O31S2
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Color White to off-white
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Synonyms
14-Glycine-Humanin (human)
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Sequence Shortening
MAPRGFSCLLLLTGEIDLPVKRRA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (262 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ying Xie, et al. Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res Clin Pract. 2014 Dec;106(3):560-6. [Content Brief]
[2]. T Wang, et al. [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. Neuroscience. 2013 Feb 12;231:70-81. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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