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Astramembrangenin (Synonyms: Cyclosieversigenin)

Cat. No.: HY-N1485
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Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge. Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties. Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression.

For research use only. We do not sell to patients.

Astramembrangenin Chemical Structure

Astramembrangenin Chemical Structure

CAS No. : 78574-94-4

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Description

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge[1]. Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties[2]. Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression[2].

In Vitro

Astramembrangenin (0-10 µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures[1].
Astramembrangenin (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type[1].
Astramembrangenin (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression[1].

Cell Viability Assay[1]

Cell Line: HEK cells
Concentration: 1 µM, 3 µM, 10 µM
Incubation Time: 3-6 days
Result: Doubled the cell growth at 6 days.

Western Blot Analysis[1]

Cell Line: Neuronal cells
Concentration: 0.3 µM
Incubation Time: 5 mins, 15 mins, 30 mins, 90 mins
Result: Suggested that CAG induces CREB activation in neuronal cells.

RT-PCR[1]

Cell Line: Neuronal cells
Concentration: 3 µM
Incubation Time: 6-48 hours
Result: Increased tert, bcl2 mRNA expression.
Molecular Weight

490.72

Formula

C₃₀H₅₀O₅

CAS No.

78574-94-4

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Astramembrangenin
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