2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. Ginkgolide B

Ginkgolide B  (Synonyms: BN-52021)

Cat. No.: HY-N0784 Purity: ≥98.0%
COA Handling Instructions

Ginkgolide B (BN-52021), an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis.

For research use only. We do not sell to patients.

Ginkgolide B Chemical Structure

Ginkgolide B Chemical Structure

CAS No. : 15291-77-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 77 In-stock
Solid
25 mg USD 70 In-stock
50 mg USD 120 In-stock
100 mg USD 180 In-stock
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500 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

Ginkgolide B Related Antibodies

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Description

Ginkgolide B (BN-52021), an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis. IC50 value: Target: In vitro: Ginkgolide B (0.2 or 0.4 μg/ml) was added to the culture medium in vitro led to increases in cell viability and decreases in the number of hippocampal cells undergoing AAPH-induced apoptosis [1]. Ginkgolide B caused a dose-related protection against dysrhythmias; the antiarrhythmic effect of ginkgolide B was comparable to that of diltiazem and superior to the activity of metoprolol. Ginkgolide B can presumably prevent the re-entry mechanism involved in the development of ischemia-induced rhythm disturbances [2]. In vivo: Oral administration of ginkgolide B (2 mg/kg/day, p.o.) caused a significant increase in cell viability and a highly significant decrease in the numbers of both spontaneously occurring and AAPH-induced apoptoses.

Molecular Weight

424.40

Appearance

Solid

Formula

C20H24O10
CAS No.
SMILES

O[C@@H]1C(C2([C@H]3O)[C@](OC3=O)([H])O4)([C@@](O5)([H])C[C@H]2C(C)(C)C)C4(C5=O)[C@@](O)([C@@H]6C)[C@@]1([H])OC6=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (235.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3563 mL 11.7813 mL 23.5627 mL
5 mM 0.4713 mL 2.3563 mL 4.7125 mL
10 mM 0.2356 mL 1.1781 mL 2.3563 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 5 mg/mL (11.78 mM); Suspended solution; Need ultrasonic and warming and heat to 44°C

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (256 KB) HNMR (263 KB)

Handling Instructions (2659 KB)
References
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Ginkgolide B Related Classifications

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Keywords:

Ginkgolide B15291-77-7BN-52021BN52021BN 52021Endogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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