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Cat. No.: HY-160006

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PIM-IN-2

PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC₅₀ = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors.

For research use only. We do not sell to patients.

CAS No.: 1006699-45-1
Formula: C₁₉H₂₂N₄O₂
Molecular Weight:338.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PIM-IN-2 Chemical Structure

CAS No.: 1006699-45-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC₅₀ = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors^[1].

IC₅₀ & Target

PIM2

All Pim Isoforms :

Chemical Information

CAS No. 1006699-45-1
Molecular Weight 338.40
Formula C₁₉H₂₂N₄O₂
SMILES

OC(/C=C/C1=CC=CC(C2=NC(NCC3CCNCC3)=CN=C2)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qian K, et al. Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode [J]. Journal of medicinal chemistry, 2009, 52(7): 1814-1827. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PIM-IN-2

All Pim Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PIM-IN-2 Related Classifications

HY-160006 Related Classifications