1. Epigenetics
  2. Histone Methyltransferase
  3. UNC0321

UNC0321 

Cat. No.: HY-10930 Purity: ≥98.0%
Handling Instructions

UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.

For research use only. We do not sell to patients.

UNC0321 Chemical Structure

UNC0321 Chemical Structure

CAS No. : 1238673-32-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 132 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 116 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 840 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    UNC0321 purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Nov;131:110662.

    UNC0321 inhibits the apoptosis by targeting Rab4 in HUVEC. After the treatment (UNC0321, 200 pM) or transfection (Rab4 overexpression plasmid) for 48 h, Western Blot is performed to detect the expression of Bax, Bcl-2, Cleaved-Caspase3, Caspase3, p-AKT, AKT and Rab4. UNC0321 may play a role in promoting proliferation and anti-apoptosis by inhibiting Rab4/AKT/mTOR signaling pathway in HUVEC.
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    Description

    UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1].

    IC50 & Target[1]

    G9a

    63 pM (Ki)

    G9a

    6-9 nM (IC50)

    GLP

    15-23 nM (IC50)

    In Vitro

    In G9a ECSD and CLOT assays, the IC50 values of 9 nM and 6 nM for UNC0321 (Compound 29), respectively. In GLP ECSD and CLOT assays, the IC50 values of 15 nM and 23 nM for UNC0321, respectively[1].
    UNC0321 (Compound 3) reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    515.69

    Formula

    C₂₇H₄₅N₇O₃

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 31 mg/mL (60.11 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9391 mL 9.6957 mL 19.3915 mL
    5 mM 0.3878 mL 1.9391 mL 3.8783 mL
    10 mM 0.1939 mL 0.9696 mL 1.9391 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: ≥98.0%

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    Product Name:
    UNC0321
    Cat. No.:
    HY-10930
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