1. Apoptosis
  2. IAP
  3. Embelin

Embelin (Synonyms: Embelic acid; Emberine; NSC 91874)

Cat. No.: HY-17473 Purity: 98.75%
Handling Instructions

Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.

For research use only. We do not sell to patients.

Embelin Chemical Structure

Embelin Chemical Structure

CAS No. : 550-24-3

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10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 258 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Embelin

    Embelin purchased from MCE. Usage Cited in: Mol Neurobiol. 2014 Apr;49(2):1087-101.

    Embelin (EB) promotes TGF-β/β-catenin and inhibits STAT3 signaling in mDCs. DCs are treated with 10, 30, and 60 μM EB to investigate its effect on p-STAT3, TGF-β, β-catenin, and p-GSK-3β signaling (diluted 1:1,000).
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    Description

    Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive binding assay with Smac peptide). IC50 value: 4.1 uM [1] Target: XIAP in vitro: Embelin induced activation of caspase-9 and embelin-induced apoptosis was prevented by caspase inhibitors [2]. Treatment with subtoxic doses of Embelin broadly sensitized malignant glioma cells to TRAIL-mediated apoptosis. Notably, human astrocytes were not significantly affected by the combined treatment consisting of Embelin and TRAIL. Combined treatment with Embelin and TRAIL augmented the activation of initiator caspases-8/-9 and effector caspases-3/-7, respectively [3]. in vivo: Embelin inhibited topical edema in the mouse ear, leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase activity, and various histopathological indicators. Furthermore, embelin was effective at reducing inflammatory damage induced by chronic TPA exposure [4]. Embelin (10, 30 or 50mg/kg body weight) was administrated daily per oral route for 7days. Embelin significantly attenuated DSS-induced DAI scores and tissue MPO accumulation, which implied that it suppressed weight loss, diarrhea, gross bleeding, and the infiltrations of immune cells. Embelin administration also effectively and dose-dependently prevented shortening of colon length and enlargement of spleen size [5].

    Molecular Weight

    294.39

    Formula

    C₁₇H₂₆O₄

    CAS No.

    550-24-3

    SMILES

    O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (169.84 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3969 mL 16.9843 mL 33.9685 mL
    5 mM 0.6794 mL 3.3969 mL 6.7937 mL
    10 mM 0.3397 mL 1.6984 mL 3.3969 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.5 mg/mL (8.49 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (8.49 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    Embelin
    Cat. No.:
    HY-17473
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