FIZZ-1 (32-51) (mouse)
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia.
For research use only. We do not sell to patients.
- Formula: C98H162N26O32
- Molecular Weight:2216.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FIZZ-1 (32-51) (mouse) (11.28 nM; 24 h) shows antiapoptotic effect on mouse lung fibroblasts by reduction in activation of caspases-3 and caspase-8[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse lung fibroblasts
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Concentration:11.28 nM (25 ng/mL)
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Incubation Time:24 h
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Result:Significantly diminished TNFα/CHX-induced apoptosis by >40%.
Chemical Information
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Molecular Weight 2216.49
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Formula C98H162N26O32
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Sequence Shortening
ENKVKELLANPANYPSTVTK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chung MJ, et al. Antiapoptotic effect of found in inflammatory zone (FIZZ)1 on mouse lung fibroblasts. J Pathol. 2007 Jun;212(2):180-7. [Content Brief]
[2]. Holcomb IN, et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FIZZ-1 (32-51) (mouse) Related Classifications
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