Search Result

Results for "

heat

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSP (51) Adrenergic Receptor (1) Antibiotic (5) Apoptosis (11) Autophagy (6) Bacterial (9) Biochemical Assay Reagents (6) CRFR (1) Deubiquitinase (1) DNA/RNA Synthesis (2) Drug Metabolite (1) Endogenous Metabolite (5) ERK (2) Eukaryotic Initiation Factor (eIF) (1) Fluorescent Dye (8) Fungal (1) GABA Receptor (2) HDAC (2) Hedgehog (1) HMG-CoA Reductase (HMGCR) (6) Influenza Virus (2) IRE1 (1) JNK (1) Liposome (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) Melanocortin Receptor (1) Monoamine Oxidase (1) NF-κB (1) Orthopoxvirus (2) p38 MAPK (2) Parasite (1) Phosphatase (2) Phospholipase (1) PKA (3) Potassium Channel (8) Reactive Oxygen Species (1) SARS-CoV (1) Ser/Thr Protease (1) TGF-beta/Smad (1) Toll-like Receptor (TLR) (1) TRP Channel (4)
By Research Areas:	Cancer (48) Cardiovascular Disease (10) Infection (17) Inflammation/Immunology (11) Metabolic Disease (19) Neurological Disease (19)

By Targets:

HSP (51)

Adrenergic Receptor (1)

Antibiotic (5)

Apoptosis (11)

Autophagy (6)

Bacterial (9)

Biochemical Assay Reagents (6)

CRFR (1)

Deubiquitinase (1)

DNA/RNA Synthesis (2)

Drug Metabolite (1)

Endogenous Metabolite (5)

ERK (2)

Eukaryotic Initiation Factor (eIF) (1)

Fluorescent Dye (8)

Fungal (1)

GABA Receptor (2)

HDAC (2)

Hedgehog (1)

HMG-CoA Reductase (HMGCR) (6)

Influenza Virus (2)

IRE1 (1)

JNK (1)

Liposome (1)

Mas-related G-protein-coupled Receptor (MRGPR) (1)

Melanocortin Receptor (1)

Monoamine Oxidase (1)

NF-κB (1)

Orthopoxvirus (2)

p38 MAPK (2)

Parasite (1)

Phosphatase (2)

Phospholipase (1)

PKA (3)

Potassium Channel (8)

Reactive Oxygen Species (1)

SARS-CoV (1)

Ser/Thr Protease (1)

TGF-beta/Smad (1)

Toll-like Receptor (TLR) (1)

TRP Channel (4)

By Research Areas:

Cancer (48)

Cardiovascular Disease (10)

Infection (17)

Inflammation/Immunology (11)

Metabolic Disease (19)

Neurological Disease (19)

108

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: HSP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100110

KNK437

2 Publications Verification

heat Shock Protein Inhibitor I
HSP Cancer

KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

KNK437 2 Publications Verification heat Shock Protein Inhibitor I	HSP	Cancer
KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

HY-144867

CCT245232	HSP	Cancer
CCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) .

HY-W088089

ICG-carboxylic acid	Fluorescent Dye	Others
ICG-carboxylic acid is near-infrared (NIR) fluorescent probe. ICG is a fluorescent dye used in medical diagnostics. ICG has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue .

HY-E70217

*Uracil DNA Glycosylase (UDG/UNG), heat-sensitive* heat-sensitive UDG	Others	Cancer
Uracil DNA Glycosylase (UDG/UNG), heat-sensitive (Heat-sensitive UDG) can catalyze the hydrolysis of the N-glycosidic bond between the uracil base and the sugar phosphate backbone in the DNA chain containing uracil, releasing free uracil. Uracil DNA Glycosylase (UDG/UNG), heat-sensitive eliminates the carryover contamination dUTP-incorporated amplification products .

HY-100980

HEAT hydrochloride BE2254 hydrochloride	Adrenergic Receptor	Neurological Disease
HEAT (BE2254) hydrochloride is a selective _{alpha 1 adrenergic receptor} antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pK_is of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively .

HY-144830

6BrCaQ	HSP	Cancer
6BrCaQ is a potent *mitochondrial heat* shock protein TRAP1** inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates .

HY-125974

HM03

2 Publications Verification

HSP Cancer

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity .

HM03 2 Publications Verification	HSP	Cancer
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity .

HY-125974A

HM03 trihydrochloride	HSP	Cancer
HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity .

HY-W014102

L-Alanyl-L-glutamine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-149891

HSP90-IN-23	HSP	Cancer
HSP90-IN-23 (Comp 12-1) is an inhibitor of heat shock protein 90(HSP90) with an IC₅₀ of 9 nM. HSP90-IN-23 induces apoptosis of tumor cells and arrests the tumor cell cycle in G0/G1 phase. HSP90-IN-23 can be used for cancer research .

HY-108486

Herbimycin A	Bacterial Antibiotic	Infection
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-18669

ML346 3 Publications Verification	HSP	Cancer
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

HY-152027

HSP90-IN-18	HSP Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-18 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-152028

HSP90-IN-19	HSP	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-19 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-107599

AEG3482	JNK Apoptosis	Neurological Disease
AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .

HY-118487

OB-24	Others	Cancer
OB-24 is a potent inhibitor of heme oxygenase-1 (HO-1). Heme oxygenase-1, a member of the heat shock protein family, plays a key role as a sensor and regulator of oxidative stress. OB-24 significantly inhibited cell proliferation in vitro and tumor growth and lymph node/lung metastases in vivo. OB-24 has potential for the research of advanced prostate cancer (PCA) .

HY-145559

Cemdomespib KU-596	HSP	Metabolic Disease
Cemdomespib (KU-596) is a highly bioavailable second-generation Hsp90 modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib induces Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response .

HY-13479

EC144	HSP	Cancer
EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC₅₀ of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases . EC144 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-143880

MRGPRX1 agonist 4	Mas-related G-protein-coupled Receptor (MRGPR)	Neurological Disease
MRGPRX1 agonist 4 (compound 1t) is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC₅₀ value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can reduce behavioral heat hypersensitivity in a neuropathic pain model humanized MRGPRX1 mice. MRGPRX1 agonist 4 can be used for researching neuropathic pain .

HY-12349

H1PVAT	Others	Infection
H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation .

HY-B0779

Teprenone

3 Publications Verification

Geranylgeranylacetone
HSP Neurological Disease Cancer

Teprenone is an anti-ulcer agent, and works as an inducer of heat shock proteins (HSPs).
HY-U00398

Bimoclomol

HSP Cardiovascular Disease

Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases.

Teprenone 3 Publications Verification Geranylgeranylacetone	HSP	Neurological Disease Cancer
Teprenone is an anti-ulcer agent, and works as an inducer of heat shock proteins (HSPs).

Bimoclomol	HSP	Cardiovascular Disease
Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases.

HY-121432

Kitol	Others	Others
Kitol is peptide used for after-sun repair cosmetics. The dominant degradation reaction for vitamin A derivatives is heat-induced formation of kitols, i.e., dimers or higher oligomers. Vitamin A esters are used as a model system to evaluate microcalorimetry as a tool for monitoring the stability of heat-sensitive substances .

HY-13313

XL888

2 Publications Verification

HSP Cancer

XL888 is a heat shock protein-90 (HSP90) inhibitor, with an IC₅₀ of 24 nM.
HY-100872

KRIBB11

15+ Cited Publications

HSP Apoptosis Cancer

KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC₅₀ of 1.2 μM.

XL888 2 Publications Verification	HSP	Cancer
XL888 is a heat shock protein-90 (HSP90) inhibitor, with an IC₅₀ of 24 nM.

KRIBB11 15+ Cited Publications	HSP Apoptosis	Cancer
KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC₅₀ of 1.2 μM.

HY-10635

ABT-102	TRP Channel	Inflammation/Immunology Cancer
ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain .

HY-N10604

Dihydromaniwamycin E

Influenza Virus SARS-CoV Infection

Dihydromaniwamycin E is a heat-shock metabolite with antiviral activity against influenza and SARS-CoV-2 viruses .
HY-B1425

Ethoxyquin

HSP Reactive Oxygen Species Cancer

Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).
HY-12622

HSP70-IN-1

1 Publications Verification

HSP Cancer

HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC₅₀ of 2.3 μM.

Dihydromaniwamycin E	Influenza Virus SARS-CoV	Infection
Dihydromaniwamycin E is a heat-shock metabolite with antiviral activity against influenza and SARS-CoV-2 viruses .

Ethoxyquin	HSP Reactive Oxygen Species	Cancer
Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).

HSP70-IN-1 1 Publications Verification	HSP	Cancer
HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC₅₀ of 2.3 μM.

HY-112516

Fmoc-Lys(amino aldehyde)-Boc	Others	Others
Fmoc-Lys(amino aldehyde)-Boc is a lysine derivative, and is very sensitive to acid and heat. Fmoc-Lys(amino aldehyde)-Boc and can be used in solid phase synthesis .

HY-132995

DP-1	Drug Metabolite	Others
DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity .

HY-145927

NXP800

CCT361814
HSP Cancer

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research .

NXP800 CCT361814	HSP	Cancer
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research .

HY-W016969

2-Undecanone	Others	Infection Cancer
2-Undecanone is a volatile organic compound, which inhibits the DnaKJE-ClpB bichaperone dependent refolding of heat-inactivated bacterial luciferases. 2-Undecanone inhibits lung tumorigenesis .

HY-N6850

Calenduloside E 1 Publications Verification	HSP Endogenous Metabolite
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90) .

HY-101026

CCT251236 3 Publications Verification	HSP	Cancer
CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC₅₀ of 19 nM for inhibition of HSF1-mediated HSP72 induction.

HY-101712

TRC051384 3 Publications Verification	HSP	Neurological Disease
TRC051384 is a potent inducer of heat shock protein 70 (HSP70). TRC051384 exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 can be used for the research of ischemic stroke .

HY-124109

TRC051384 hydrochloride	HSP	Cardiovascular Disease Neurological Disease
TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). TRC051384 hydrochloride exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 hydrochloride can be used for the research of ischemic stroke .

HY-D0193

Ponceau 4R 1 Publications Verification Acid Red 18; New Coccine	Fluorescent Dye	Others
Ponceau 4R is a synthetic colorant that can be used for food coloring. Ponceau 4R is a strawberry red azo dye that can be used in a variety of foods, usually synthesized from aromatic hydrocarbons, and is stable to light, heat, and acids .

HY-106443A

Arimoclomol maleate 2 Publications Verification BRX-220	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP) . Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system .

HY-N6679A

10,11-Dehydrocurvularin	HSP TGF-beta/Smad	Infection Cancer
10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity .

HY-P3029

Phospholipase A2 PLA2	Phospholipase	Others
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

HY-111036

AMG0347	TRP Channel	Others
AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC₅₀ = 0.2 nm), protons (IC₅₀= 0.8 nm), or capsaicin (IC₅₀ = 0.7 nm) .

HY-114664

KNK423	HSP	Infection Cancer
KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research .

HY-106443

Arimoclomol BRX-220 free base	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) . Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system .

HY-P0222

PKI(5-24) 3 Publications Verification	PKA	Others
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-111524

CPUY201112	HSP Apoptosis	Cancer
CPUY201112 is a potent heat shock protein Hsp90 inhibitor with K_d of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research .

HY-106443B

Arimoclomol citrate BRX-220 citrate	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP) . Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system .

HY-P0222A

PKI(5-24) TFA	PKA	Others
PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-N10352

4-epi-Withaferin A	Others	Cancer
4-epi-Withaferin A (compound 28) is the analogue of Withaferin A. 4-epi-Withaferin A enhances cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). 4-epi-Withaferin A has the potential for the research of protein aggregation-associated diseases by stimulating cellular defense mechanisms .

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment .

Cat. No.	Product Name	Type

HY-W088089

ICG-carboxylic acid	Fluorescent Dyes/Probes
ICG-carboxylic acid is near-infrared (NIR) fluorescent probe. ICG is a fluorescent dye used in medical diagnostics. ICG has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue .

HY-D0193

Ponceau 4R 1 Publications Verification Acid Red 18; New Coccine	Dyes
Ponceau 4R is a synthetic colorant that can be used for food coloring. Ponceau 4R is a strawberry red azo dye that can be used in a variety of foods, usually synthesized from aromatic hydrocarbons, and is stable to light, heat, and acids .

HY-128868

FITC-Dextran (MW 10000)

Maximum Cited Publications

28 Publications Verification

Fluorescent Dyes/Probes

FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-D1905

ICG acid	Fluorescent Dyes/Probes
ICG acid is a fluorescent dye used in medical diagnostics. ICG acid has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue. ICG acid has been used in fluorescence-guided surgery to identify critical structures, including intra-abdominal tumors .

HY-D0193A

Ponceau 4R (85%) Acid Red 18 (85%); New Coccine (85%)	Dyes
Ponceau 4R (85%)(Acid Red 18 (85%); New Coccine (85%))is a synthetic colourant that may be used as a food colouring. Ponceau 4R (85%)is a strawberry red azo dye which can be used in a variety of food products, and is usually synthesized fromaromatic hydrocarbons; it is stable to light, heat, and acid but fades in the presence of ascorbic acid .

HY-128868A

FITC-Dextran (MW 4000)

Maximum Cited Publications

28 Publications Verification

Fluorescent Dyes/Probes

FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868D

FITC-Dextran (MW 40000)

1 Publications Verification

Fluorescent Dyes/Probes

FITC-Dextran (MW 40000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 40000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 40000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868G

FITC-Dextran (MW 150000)

Fluorescent Dyes/Probes

FITC-Dextran (MW 150000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=491 nm; Em=518 nm). FITC-Dextran (MW 150000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 150000) can be used in perfusion studies in animals or in fluorescence microlymphography, to study processes that affect the permeability of the blood brain barrier (BBB) . FITC-Dextran (MW 150000) can be used as fluorescent probe to study cell permeability .

HY-128868B

FITC-Dextran (MW 3000-5000)

Dyes

FITC-Dextran (MW 3000-5000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 3000-5000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 3000-5000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption . Storage: protect from light.

Cat. No.	Product Name	Type

HY-W099538

Dilauryl thiodipropionate

Dilauryl 3,3'-Thiodipropionate

Biochemical Assay Reagents

Dilauryl thiodipropionate (DLTDP), which is a sulfur-containing antioxidant commonly used to stabilize polymers and plastics against degradation caused by heat, oxygen, and UV light, acts to scavenge free radicals and others that may cause polymer chain scission and cross-linked active substances, in addition, DLTDP has been used as an additive to lubricants, oils and other industrial fluids to improve their oxidation stability, the long hydrocarbon chain in DLTDP makes it low volatility and compatible with many materials and Good compatibility with substrates.

HY-P3029

Phospholipase A2 PLA2	Biochemical Assay Reagents
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

HY-142980

Dioleoylphosphatidylglycerol DOPG	Drug Delivery
Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5

Biochemical Assay Reagents

Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. .

HY-B1610M

Sodium Citrate Buffer, 0.5M, pH 6.5

Biochemical Assay Reagents

Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .

HY-B1610N

Sodium Citrate Buffer, 0.1M, pH 4.0

Biochemical Assay Reagents

Sodium citrate buffer, 0.1M, pH 4.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.1M, pH 4.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.1M, pH 4.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.1M, pH 4.0 is used in the hydration of liposome film .

HY-B1610J

Sodium Citrate Buffer, 0.5M, pH 5.0

Biochemical Assay Reagents

Sodium citrate buffer, 0.5M, pH 5.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 5.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 5.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.5M, pH 5.0 is used as solution for captisol in animal tumor models .

HY-108717

Proteinase K 5 Publications Verification Protease K	Biochemical Assay Reagents
Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection .

Cat. No.	Product Name	Target	Research Area

HY-W014102

L-Alanyl-L-glutamine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-P2695

STh	Peptides	Infection
STh, an Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide encompassing three disulfide bridges. STh is an antigen of interest in the search for a broad coverage enterotoxigenic Escherichia coli (ETEC) vaccine .

HY-P5089

Enterotoxin STp (E. coli)

Peptides Infection

Enterotoxin STp (E. coli) is a heat-stable enterotoxin that can be used in vaccine research .
HY-P5236

Acetyl tetrapeptide-22

Peptides Others

Acetyl tetrapeptide-22 is a bioactive peptide with repair skin effect and has been reported used as a cosmetic ingredient .

HY-P3029

Phospholipase A2 PLA2	Phospholipase	Others
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

HY-P0222

PKI(5-24) 3 Publications Verification	PKA	Others
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-P0222A

PKI(5-24) TFA	PKA	Others
PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment .

HY-P3130

Stresscopin-related peptide (human)	CRFR	Neurological Disease Inflammation/Immunology
Stresscopin-related peptide (human) is a specific ligand for the type 2 CRH receptor. Stresscopin-related peptide (human) suppresses food intake, delayed gastric emptying and decreases heat-induced edema. Stresscopin-related peptide (human) maintains homeostasis after stress, and can be used in the research of stress-related diseases .

HY-P3930

PKI (5-24),amide IP20-amide	PKA	Neurological Disease
PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependent protein kinase. PKI (5-24),amide is a potent cAMP-dependent protein kinase (PKA) (PKA) inhibitor with a K_i of 2.3 nM .

Species:	Human (28) Rat (1) Mouse (2) E.coli (2)
Tag:	His (27) SUMO (1) Tag Free (4) Myc (1) GST (2)
Source:	HEK293 (3) P. pastoris (1) Sf9 insect cells (1) E. coli (28)

Cat. No.	Compare	Product Name	Species	Source

HY-P71824

	HSP70/DnaK Protein, E. coli (P.pastoris, His) dnaK; HSP70; heat shock 70kDa protein; heat shock protein 70	E.coli	P. pastoris
	HSP70/DnaK protein, a molecular chaperone, responds primarily to stress, notably heat shock. It plays a crucial role in aiding the proper folding of proteins during cellular stress, preventing misfolding or aggregation. The chaperone activity is vital for cellular homeostasis and survival under adverse conditions, where maintaining correct protein conformation becomes challenging. HSP70/DnaK's ability to recognize and assist in refolding misfolded or denatured proteins is essential for cellular resilience, preventing proteotoxicity induced by stressors, especially elevated temperatures. HSP70/DnaK Protein, E. coli (P.pastoris, His) is the recombinant E. coli-derived HSP70/DnaK protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of HSP70/DnaK Protein, E. coli (P.pastoris, His) is 638 a.a., with molecular weight of ~71.1 kDa.

HY-P71487

	HtpG Protein, E.coli htpG; b0473; JW0462; Chaperone protein HtpG; heat shock protein C62.5; heat shock protein HtpG; High temperature protein G	E.coli	E. coli
	HtpG protein, a molecular chaperone, functions with ATPase activity and homodimerizes, demonstrating unique oligomerization at 65 degrees Celsius. HtpG Protein, E.coli is the recombinant E. coli-derived HtpG protein, expressed by E. coli , with tag free. The total length of HtpG Protein, E.coli is 624 a.a., with molecular weight of ~71.4 kDa.

HY-P701385

	HSPA2 Protein, Human (His) HSPA2; heat shock-related 70 kDa protein 2; heat shock 70 kDa protein 2	Human	E. coli
	The HSPA2 protein is a molecular chaperone that protects the proteome, aids in protein folding and transport, activates proteolysis, and regulates protein complex formation. It ensures accurate protein folding and degradation, with substrate affinity related to its nucleotide status. HSPA2 Protein, Human (His) is the recombinant human-derived HSPA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPA2 Protein, Human (His) is 638 a.a., .

HY-P72238

	HSP90AA1 Protein, Human (His-SUMO) heat shock 86 kDa; heat shock protein 90kDa alpha cytosolic class A member 1; heat shock protein 90kDa alpha cytosolic class B member 1; heat shock protein HSP 90 alpha ; heat shock protein HSP 90 beta; heat shock protein HSP 90-alpha; HS90A_HUMAN; HSP 84; HSP 86; Hsp 90; HSP86; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPCAL1 ; HSPCAL4; Renal carcinoma antigen NY-REN-38	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HSP90AA1 Protein, Human (His-SUMO) is 224 a.a., with molecular weight of ~43 kDa.

HY-P70844

	HSPB2 Protein, Human (His) heat shock protein beta-2; HspB2; DMPK-binding protein; MKBP;	Human	E. coli
	HSPB2 Protein potentially regulates the kinase DMPK, enhancing its activity and influencing cellular processes. The specific mechanisms and broader implications in cellular signaling pathways require elucidation. Comprehensive studies are essential to unravel the precise molecular pathways and functional significance of the HSPB2-DMPK interplay, shedding light on its potential contributions to cellular regulation and signaling cascades. HSPB2 Protein, Human (His) is the recombinant human-derived HSPB2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSPB2 Protein, Human (His) is 182 a.a., with molecular weight of ~22.0 kDa.

HY-P70406

	HSF2 Protein, Human (His) rHuheat shock factor protein 2/HSF2, His; heat Shock Factor Protein 2; HSF 2; heat Shock Transcription Factor 2; HSTF 2; HSF2; HSTF2	Human	E. coli
	As a DNA-binding protein, HSF2 protein has specific affinity for the heat shock promoter element (HSE), thereby activating transcription. Notably, in higher eukaryotes, the ability of HSF2 to bind to HSE depends on the exposure of cells to heat shock. HSF2 Protein, Human (His) is the recombinant human-derived HSF2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSF2 Protein, Human (His) is 126 a.a., with molecular weight of ~26.0 kDa.

HY-P73918

	HSF1 Protein, Human (His) heat shock factor protein 1; HSF1; HSTF 1	Human	E. coli
	HSF1, a stress-inducible transcription factor, orchestrates the heat shock response by activating heat shock genes through binding to heat shock elements (HSEs). In unstressed cells, it remains inactive in a multichaperone complex. Upon stress, HSF1 undergoes homotrimerization, binds to HSEs, and activates HSP gene transcription. It also participates in various cellular functions, including regulation of mitotic progression, repression of c-fos gene, and negative regulation of non-homologous end joining repair. Additionally, HSF1 plays a role in HIV-1 transcriptional reactivation. HSF1 Protein, Human (His) is the recombinant human-derived HSF1 protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of HSF1 Protein, Human (His) is 528 a.a., with molecular weight of ~67 kDa.

HY-P73915

	HSPA8/HSC70 Protein, Human (His, Solution) heat shock cognate 71 kDa protein; LAP-1; HSPA8; HSC70	Human	E. coli
	HSPA8/HSC70 is a molecular chaperone that protects the proteome and aids in peptide folding, transport, chaperone-mediated autophagy, and protein complex regulation. It is central to quality control, ensuring correct folding and targeting misfolded proteins for degradation through ATP-dependent cycles. HSPA8/HSC70 Protein, Human (His, Solution) is the recombinant human-derived HSPA8/HSC70 protein, expressed by E. coli , with N-His labeled tag. The total length of HSPA8/HSC70 Protein, Human (His, Solution) is 646 a.a., with molecular weight of ~65 kDa.

HY-P73915A

	HSPA8/HSC70 Protein, Human (N-His) heat shock cognate 71 kDa protein; LAP-1; HSPA8; HSC70	Human	E. coli
	HSPA8/HSC70 is a molecular chaperone that protects the proteome and aids in peptide folding, transport, chaperone-mediated autophagy, and protein complex regulation. It is central to quality control, ensuring correct folding and targeting misfolded proteins for degradation through ATP-dependent cycles. HSPA8/HSC70 Protein, Human (N-His) is the recombinant human-derived HSPA8/HSC70 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPA8/HSC70 Protein, Human (N-His) is 646 a.a., with molecular weight of ~65 kDa.

HY-P74878

	HSP27/HSPB1 Protein, Human (His) heat shock protein beta-1; HspB1; HSP 27; SRP27; HSPB1; HSP28	Human	E. coli
	The HSP27/HSPB1 protein is a small heat shock protein that acts as a molecular chaperone, possibly maintaining denatured proteins in a foldable state. In addition to its chaperone role, it crucially enhances stress resistance and contributes to actin organization. HSP27/HSPB1 Protein, Human (His) is the recombinant human-derived HSP27/HSPB1 protein, expressed by E. coli , with C-His labeled tag. The total length of HSP27/HSPB1 Protein, Human (His) is 205 a.a., with molecular weight of ~28 kDa.

HY-P71537

	TRAP1 Protein, Human (GST) heat shock protein 75kDa; heat shock protein 75kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein	Human	E. coli
	As a chaperone with ATPase activity, TRAP1 protein plays a crucial role in protecting mitochondrial function and polarization, especially downstream of PINK1 and mitochondrial complex I. TRAP1 acts as a negative regulator of mitochondrial respiration, affecting the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1 Protein, Human (GST) is the recombinant human-derived TRAP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRAP1 Protein, Human (GST) is 249 a.a., with molecular weight of ~54.5 kDa.

HY-P70945

	HSPB11 Protein, Human (His) heat Shock Protein Beta-11; Hspb11; Placental Protein 25; PP25; HSPB11; C1orf41	Human	E. coli
	The HSPB11 protein is an important component of IFT complex B and is indispensable for sonic eager/SHH signaling. It promotes intraflagellar transport in ciliated tissues such as kidney and testis, mediating the transport of SHH components. HSPB11 Protein, Human (His) is the recombinant human-derived HSPB11 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPB11 Protein, Human (His) is 144 a.a., with molecular weight of ~21.0 kDa.

HY-P73105

	HSP70/HSPA1B Protein, Human (SF9, His) heat shock 70 kDa protein 1B; HSP70-2; HSPA1B; HSP72	Human	Sf9 insect cells
	HSP70/HSPA1B protein, a vital molecular chaperone, ensures proteome integrity by protecting from stress, aiding protein folding, activating proteolysis, and regulating protein complex assembly. It maintains accurate folding through ATP cycles and co-chaperones like HSP40s, BAG1/2/3, HOPX, and STUB1. Its acetylation state modulates competitive binding with HOPX and STUB1, dictating roles in protein refolding and degradation during stress. Beyond protein homeostasis, HSP70 regulates centrosome integrity, influences SMAD3 and FOXP3 degradation, and acts as a post-attachment receptor in rotavirus A infection. HSP70/HSPA1B Protein, Human (SF9, His) is the recombinant human-derived HSP70/HSPA1B protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of HSP70/HSPA1B Protein, Human (SF9, His) is 640 a.a., with molecular weight of ~72.2 kDa.

HY-P74877

	HSP70/HSPA1A Protein, Human (HEK293, His) heat shock 70 kDa protein 1A; HSP70-1; HSPA1A; HSP72	Human	HEK293
	The HSP70/HSPA1A protein is an important molecular chaperone that protects proteome integrity by counteracting stress, aiding protein folding, activating misfolded proteolysis, and regulating protein complex dynamics. In protein quality control systems, it ensures accurate protein folding, controls substrate targeting for degradation through the ATP cycle, and interacts with co-chaperones such as HSP40, BAG1/2/3, HOPX, and STUB1. HSP70/HSPA1A Protein, Human (HEK293, His) is the recombinant human-derived HSP70/HSPA1A protein, expressed by HEK293 , with N-His labeled tag. The total length of HSP70/HSPA1A Protein, Human (HEK293, His) is 640 a.a., with molecular weight of ~85 kDa.

HY-P70331

	HSP40/DNAJB1 Protein, Human (His) rHuDnaJ homolog subfamily B member 1/HSP40, His; DnaJ Homolog Subfamily B Member 1; DnaJ Protein Homolog 1; heat Shock 40 kDa Protein 1; HSP40; heat Shock Protein 40; Human DnaJ Protein 1; hDj-1; DNAJB1; DNAJ1; HDJ1; HSPF1	Human	E. coli
	HSP40/DNAJB1 protein, a key player in cellular processes, interacts with HSP70 to enhance ATPase activity and stimulate HSC70-HIP association. It negatively regulates HSF1 transcriptional activity in heat shock response recovery, and interacts with DNAJC3 and HSF1, inhibiting their transcriptional activity. These multifaceted interactions showcase HSP40/DNAJB1's intricate regulatory functions in stress responses and protein folding. HSP40/DNAJB1 Protein, Human (His) is the recombinant human-derived HSP40/DNAJB1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSP40/DNAJB1 Protein, Human (His) is 339 a.a., with molecular weight of ~38.0 kDa.

HY-P701242

	Heat Stable FGF-basic Protein, Human 4 Publications Verification Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2; FGF2; FGFB	Human	E. coli
	FGF basic, or bFGF (fibroblast growth factor basic), initiates at an alternative CUG codon, marking a distinctive feature in translational initiation. This alternative start codon plays a pivotal role in regulating the expression and functional properties of FGF basic. Heat Stable FGF-basic Protein, Human is the recombinant human-derived Heat Stable FGF-basic protein, expressed by E. coli , with tag free. The total length of Heat Stable FGF-basic Protein, Human is 154 a.a., with molecular weight of ~17.1 kDa.

HY-P71666

	GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) Gucy2c; Guc2c; heat-stable enterotoxin receptor; STA receptor; EC 4.6.1.2; Guanylyl cyclase C; GC-C; Intestinal guanylate cyclase	Rat	HEK293
	GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP. As a receptor for E. coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling. GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) is the recombinant rat-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with N-His, C-Myc labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) is 407 a.a., with molecular weight of ~51.4 kDa.

HY-P70372

	Ribonuclease UK114/HRSP12 Protein, Human (His) rHuRibonuclease UK114/HRSP12, His; Ribonuclease UK114; 14.5 kDa Translational Inhibitor Protein; p14.5; heat-Responsive Protein 12; UK114 Antigen Homolog; HRSP12; PSP	Human	E. coli
	The ribonuclease UK114/HRSP12 protein catalyzes the hydrolytic deamination of enamine/imine intermediates, reducing the potential toxicity of these reactive metabolites by releasing ammonia. Ribonuclease UK114/HRSP12 Protein, Human (His) is the recombinant human-derived Ribonuclease UK114/HRSP12 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Ribonuclease UK114/HRSP12 Protein, Human (His) is 137 a.a., with molecular weight of 14-16 kDa.

HY-P7872

	Alpha-crystallin A chain/CRYAA Protein, Human (His) rHuAlpha-crystallin A chain/CRYAA, His; Alpha-Crystallin A Chain; heat Shock Protein Beta-4; HspB4; Alpha-Crystallin A Chain; Short Form; CRYAA; CRYA1; HSPB4	Human	E. coli
	Alpha-crystallin A chain/CRYAA Protein, Human (His) is a recombinant Alpha-crystallin A chain protein with a His tag. Alpha-crystallin A chain/CRYAA is a small heat shock protein and molecular chaperone that prevents nonspecific aggregation of denaturing proteins. Several point mutations in the alphaA-crystallin gene cause congenital human cataracts by unknown mechanisms.

HY-P7873

	Alpha-crystallin B chain/CRYAB Protein, Human (His) rHuAlpha-crystallin B chain/CRYAB, His; Alpha-Crystallin B Chain; Alpha(B)-Crystallin; heat Shock Protein Beta-5; HspB5; Renal Carcinoma Antigen NY-REN-27; Rosenthal Fiber Component; CRYAB; CRYA2	Human	E. coli
	Alpha-crystallin B chain/CRYAB Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. CRYAB is an important member of the small heat shock protein family, and plays a protective role in neurological inflammation.

HY-P70933

	HSPB8 Protein, Human (His) heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22; HSPB8; CRYAC; E2IG1; HSP22	Human	E. coli
	The HSPB8 protein exhibits temperature-dependent chaperone activity and functions as a monomer in its molecular form. It interacts with other cellular proteins to form complexes critical for cellular homeostasis. HSPB8 Protein, Human (His) is the recombinant human-derived HSPB8 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSPB8 Protein, Human (His) is 196 a.a., with molecular weight of ~23.0 kDa.

HY-P701386

	HSPBP1 Protein, Human HSPBP1; Hsp70-binding protein 1; HspBP1; heat shock protein-binding protein 1; Hsp70-binding protein 2; HspBP2; Hsp70-interacting protein 1; Hsp70-interacting protein 2	Human	E. coli
	HSPBP1 protein regulates HSPA1A chaperone activity by inducing conformational changes in the ATP-binding domain and disrupting ATP binding. This interference inhibits the STUB1-mediated ubiquitination process and blocks chaperone-assisted degradation of immature CFTR. HSPBP1 Protein, Human is the recombinant human-derived HSPBP1 protein, expressed by E. coli , with tag free. The total length of HSPBP1 Protein, Human is 276 a.a., .

HY-P701387

	HSPBP1 Protein, Human (His) HSPBP1; Hsp70-binding protein 1; HspBP1; heat shock protein-binding protein 1; Hsp70-binding protein 2; HspBP2; Hsp70-interacting protein 1; Hsp70-interacting protein 2	Human	E. coli
	HSPBP1 protein regulates HSPA1A chaperone activity by inducing conformational changes in the ATP-binding domain and disrupting ATP binding. This interference inhibits the STUB1-mediated ubiquitination process and blocks chaperone-assisted degradation of immature CFTR. HSPBP1 Protein, Human (His) is the recombinant human-derived HSPBP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPBP1 Protein, Human (His) is 276 a.a., .

HY-P76766A

	CARHSP1 Protein, Human Calcium-regulated heat-stable protein 1; Calcium-regulated heat-stable protein of 24 kDa; CRHSP-24	Human	E. coli
	The CARHSP1 protein critically regulates post-transcriptional gene expression by binding to mRNA, affecting its stability and influencing RNA homeostasis. Furthermore, in vitro binding of CARHSP1 to single-stranded DNA demonstrates the versatility of the molecular interaction. CARHSP1 Protein, Human is the recombinant human-derived CARHSP1 protein, expressed by E. coli , with tag free. The total length of CARHSP1 Protein, Human is 146 a.a., with molecular weight of 18-23 kDa.

HY-P76766

	CARHSP1 Protein, Human (His) Calcium-regulated heat-stable protein 1; Calcium-regulated heat-stable protein of 24 kDa; CRHSP-24	Human	E. coli
	CARHSP1 Protein critically regulates post-transcriptional gene expression by binding to mRNA, influencing its stability and impacting RNA homeostasis. Additionally, CARHSP1's in vitro binding to single-stranded DNA suggests versatility in molecular interactions. The protein, forming homodimers, hints at functional relevance in its dimeric state. Interactions with STYX underscore CARHSP1's association with specific partners and potential roles in larger molecular complexes or signaling pathways. CARHSP1 Protein, Human (His) is the recombinant human-derived CARHSP1 protein, expressed by E. coli, with N-6*His labeled tag. The total length of CARHSP1 Protein, Human (His) is 147 a.a., with molecular weight of ~21 kDa.

HY-P73916

	HSP60 Protein, Mouse (His) 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1	Mouse	E. coli
	The HSP60 protein, together with Hsp10, contributes to the import and assembly of mitochondrial proteins. It ensures correct folding and prevents incorrect folding under stressful conditions. HSP60 Protein, Mouse (His) is the recombinant mouse-derived HSP60 protein, expressed by E. coli , with N-His labeled tag. The total length of HSP60 Protein, Mouse (His) is 572 a.a., with molecular weight of ~58 kDa.

HY-P73917

	HSP60 Protein, Human (His-GST) 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1	Human	E. coli
	The HSP60 protein is a mitochondrial chaperone that facilitates protein import and assembly. HSP60 Protein, Human (His-GST) is the recombinant human-derived HSP60 protein, expressed by E. coli , with N-His, N-GST labeled tag. The total length of HSP60 Protein, Human (His-GST) is 572 a.a., with molecular weight of 52-65 kDa.

HY-P73916A

HSP60 Protein, Mouse (N-His)

60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1
Mouse E. coli

HY-P70116

	Cornulin Protein, Human (His) rHuCornulin, His; Cornulin; 53 kDa Putative Calcium-Binding Protein; 53 kDa Squamous Epithelial-Induced Stress Protein; 58 kDa heat Shock Protein; Squamous Epithelial heat Shock Protein 53; Tumor-Related Protein; CRNN; C1orf10; DRC1; PDRC1; SEP53	Human	E. coli
	Cornulin protein is critical in cell dynamics, promoting proliferation and promoting G1/S cell cycle progression, inducing the key regulator CCND1. It actively participates in the NFKB1 and PI3K/AKT pathways and responds to pro-inflammatory cytokines. Cornulin Protein, Human (His) is the recombinant human-derived Cornulin protein, expressed by E. coli , with N-6*His labeled tag. The total length of Cornulin Protein, Human (His) is 140 a.a., with molecular weight of ~17.0 kDa.

HY-P76283

	HSP10/EPF Protein, Human (His) 1 Publications Verification 10 kDa heat shock protein, mitochondrial; Hsp10; Chaperonin 10; CPN10; EPF; HSPE1	Human	E. coli
	The HSP10/EPF protein is a cochaperone that plays a role in mitochondrial protein import and assembly. HSP10/EPF Protein, Human (His) is the recombinant human-derived HSP10/EPF protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of HSP10/EPF Protein, Human (His) is 102 a.a., with molecular weight of ~13 KDa.

HY-P71186

	PAP Protein, Human (His) 28 kDa heat- and Acid-Stable Phosphoprotein; PDGF-Associated Protein; PAP; PDGFA-Associated Protein 1; PAP1; PDAP1; HASPP28	Human	E. coli
	PAP proteins play a dual regulatory role in cell growth, exhibiting different effects depending on the specific growth factors involved. In fibroblasts, it exerts a positive regulatory effect by enhancing PDGFA-stimulated cell growth. PAP Protein, Human (His) is the recombinant human-derived PAP protein, expressed by E. coli , with N-6*His labeled tag. The total length of PAP Protein, Human (His) is 181 a.a., with molecular weight of ~30.0 kDa.

HY-P71298

	Serpin H1 Protein, Human (HEK293, His) Serpin H1; 47 kDa heat Shock Protein; Arsenic-Transactivated Protein 3; AsTP3; Cell Proliferation-Inducing Gene 14 Protein; Collagen-Binding Protein; Colligin; Rheumatoid Arthritis-Related Antigen RA-A47; SERPINH1; CBP1; CBP2; HSP47; SERPINH2	Human	HEK293
	Serpin H1 protein exhibits a specific affinity for collagen, indicating its role as a chaperone in the biosynthetic pathway of collagen. This suggests its potential contribution to collagen synthesis, emphasizing its importance in maintaining tissue integrity and modulating cellular responses related to collagen metabolism. Serpin H1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin H1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin H1 Protein, Human (HEK293, His) is 400 a.a., with molecular weight of ~51.0 kDa.

HY-P70415

	EIF4EBP1 Protein, Human (His) rHuEukaryotic translation initiation factor 4E-binding protein 1/EIF4EBP1, His; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1; 4E-BP1; eIF4E-Binding Protein 1; Phosphorylated heat- and Acid-Stable Protein Regulated by Insulin 1; PHAS-I; EIF4EBP1	Human	E. coli
	EIF4EBP1 is a translation initiation repressor protein that complexly regulates EIF4E activity. In the hypophosphorylated state, EIF4EBP1 competes with EIF4G1/EIF4G3 to inhibit translation by binding to EIF4E. EIF4EBP1 Protein, Human (His) is the recombinant human-derived EIF4EBP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of EIF4EBP1 Protein, Human (His) is 118 a.a., with molecular weight of ~17.0 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P80708

Hsc70 Antibody heat shock cognate 71 kDa protein (heat shock 70 kDa protein 8)	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
Hsc70 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to Hsc70. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P83429

Hsp20 Antibody (YA3174)

HSPB6; HEL55; Hsp20; heat-shock 20 kDa like-protein p20
WB, IHC-P, FC Human, Mouse, Rat
HY-P83311

HspA2 Antibody (YA3056)

HSPA2; heat shock 70kD protein 2; HSP70-2; HSP70-3; heat shock 70 kDa protein 2; heat shock 70kDa protein 2
WB, IHC-P Human, Mouse, Rat
HY-P83427

HspA4 Antibody (YA3172)

HSPA4; APG2; heat shock 70 kDa protein 4; HSP70RY; heat shock 70-related protein APG-2
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P83202

HspA12A Antibody (YA2947) FLJ13874 antibody; heat shock 70 kDa protein 12A antibody; heat shock 70kD protein 12A antibody; heat shock 70kDa protein 12A antibody; HS12A_HUMAN antibody; Hspa12a antibody; KIAA0417 antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P81052

HSF1 Antibody (YA896) HSF1; HSTF1; heat shock factor protein 1; HSF 1; heat shock transcription factor 1; HSTF 1	WB, IHC-P, ICC/IF, IP, FC	Human
HSF1 Antibody (YA896) is an unconjugated, approximately 57-80 kDa, rabbit-derived, anti-HSF1 (YA896) monoclonal antibody. HSF1 Antibody (YA896) can be used for: WB, IHC-P, ICC/IF, IP, FC expriments in human background without labeling.

HY-P82490

Hsf2 Antibody (YA2235)

HSF2; HSTF2; heat shock factor protein 2; HSF 2; heat shock transcription factor 2; HSTF 2
WB, ICC/IF, FC Human

HY-P80709

Hsp27 Antibody (YA732) HSPB1; HSP27; HSP28; heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, ICC/IF	Human, Monkey
Hsp27 Antibody (YA732) is a non-conjugated and Mouse origined monoclonal antibody about 23 kDa, targeting to Hsp27 (7E5). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Monkey.

HY-P80823

Phospho-Hsp27 (Ser78) Antibody HSPB1; HSP27; HSP28; heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P, ICC/IF	Human
Phospho-Hsp27 (Ser78) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Phospho-Hsp27 (Ser78). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80824

Phospho-Hsp27 (Ser82) Antibody HSPB1; HSP27; HSP28; heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P	Human
Phospho-Hsp27 (Ser82) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Phospho-Hsp27 (Ser82). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P80714

Hsp90 alpha/beta Antibody HSP90AA1; HSP90A; HSPC1; HSPCA; heat shock protein HSP 90-alpha; heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; heat shock protein HSP 90-beta; HSP 90; heat shock 84 kDa; HSP 84; HSP84	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
Hsp90 alpha/beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Hsp90 alpha/beta. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80822

Phospho-HSF1 (Ser303/Ser307) Antibody HSF1; HSTF1; heat shock factor protein 1; HSF 1; heat shock transcription factor 1; HSTF 1	WB, IHC-P	Human
Phospho-HSF1 (Ser303/Ser307) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 57 kDa, targeting to Phospho-HSF1 (Ser303/Ser307). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81050

Phospho-HSF1 (Ser326) Antibody(YA894) HSF1; HSTF1; heat shock factor protein 1; HSF 1; heat shock transcription factor 1; HSTF 1	WB, IF-Cell, IHC-P, IP, FC	Human
Phospho-HSF1 (Ser326) Antibody(YA894) is an unconjugated, approximately 57 kDa, rabbit-derived, anti-HSF1 (Ser326)(YA894) monoclonal antibody. Phospho-HSF1 (Ser326) Antibody(YA894) can be used for: WB, IF-Cell, IHC-P, IP, FC expriments in human background without labeling.

HY-P83258

HspA14 Antibody (YA3003)

HSPA14; HSP60; HSP70L1; heat shock 70 kDa protein 14; HSP70-like protein 1; heat shock protein HSP60
WB, ICC/IF, IP Human, Mouse

HY-P80711

Hsp60 Antibody (YA730) HSPD1; HSP60; 60 kDa heat shock protein; mitochondrial; 60 kDa chaperonin; Chaperonin 60; CPN60; heat shock protein 60; HSP-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein	WB, ICC/IF, IP	Human, Mouse, Rat
Hsp60 Antibody (YA730) is a non-conjugated and Mouse origined monoclonal antibody about 61 kDa, targeting to Hsp60 (6C8). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80710

Hsp40 Antibody DNAJB1; DNAJ1; HDJ1; HSPF1; DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; heat shock 40 kDa protein 1; HSP40; heat shock protein 40; Human DnaJ protein 1; hDj-1	WB	Human
Hsp40 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 38 kDa, targeting to Hsp40. It can be used for WB assays with tag free, in the background of Human.

HY-P83003

DNAJA1 Antibody (YA2748) DNAJA1; DNAJ2; HDJ2; HSJ2; HSPF4; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; HSDJ; heat shock 40 kDa protein 4; heat shock protein J2; HSJ-2; Human DnaJ protein 2; hDj-2	WB, IP, FC	Human, Mouse, Rat

HY-P82868

Hsp110 Antibody (YA2613)

Antigen NY-CO-25; heat shock protein 105 kDa; HS105; HSP105; HSP105A; HSP105B; HSP110; HSPH1
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

HY-P80696

GRP78 BiP Antibody (YA746) HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP	WB, ICC/IF, IP	Human, Mouse, Rat
GRP78 BiP Antibody (YA746) is a non-conjugated and Mouse origined monoclonal antibody about 72 kDa, targeting to GRP78 BiP (4F11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83410

GRP75 Antibody (YA3155) HSPA9; GRP75; HSPA9B; Stress-70 protein; mitochondrial; 75 kDa glucose-regulated protein; GRP-75; heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74	WB	Human, Mouse, Rat

HY-P82872

HspB8 Antibody (YA2617) HSPB8; CRYAC; E2IG1; HSP22; PP1629; heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22	WB, IHC-P, ICC/IF	Human, Mouse, Rat

HY-P82445

Cpn10 Antibody (YA2190)

HSPE1; 10 kDa heat shock protein; mitochondrial; Hsp10; 10 kDa chaperonin; Chaperonin 10; CPN10; Early-pregnancy factor; EPF
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82278

AHA1 Antibody (YA2023)

AHSA1; C14orf3; HSPC322; Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38
WB, IP Human, Mouse, Rat

HY-P80526

4E BP1 Antibody EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
4E BP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 13 kDa, targeting to 4E BP1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P80786

Phospho-4E BP1 (Thr46) Antibody EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat
Phospho-4E BP1 (Thr46) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 13 kDa, targeting to Phospho-4E BP1 (Thr46). It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

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