L-Alanyl-L-glutamine
Based on 2 publication(s) in Google Scholar
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.84%
- CAS. Nr.: 39537-23-0
- Formel: C8H15N3O4
- Molecular Weight:217.22
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-N0390
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HY-W013494
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Pyruvic acid sodiumEndogenous Metabolite -
HY-D0889R
Glycylglycine (Standard)Endogenous Metabolite -
HY-D0844
Glutathione oxidizedAntioxidant -
HY-D0889
GlycylglycineiNOS Inhibitor -
HY-W016785
Glycyl-L-valineDipeptide -
HY-W014102R
L-Alanyl-L-glutamine (Standard) -
HY-W013494R
L-Carnosine (Standard)
Publications Citing Use of MedChemExpress (MCE) L-Alanyl-L-glutamine
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Biologische Aktivität
Beschreibung
In Vitro
L-Alanyl-L-glutamine (2 mM; 24 hours) partially or fully attenuates chronic insulin secretion, and IR-β and COX IV levels which are decreased when β-cells were exposed to macrophages following stimulation in vitro (IMMs)[1].
L-Alanyl-L-glutamine -dependent β-cell protection mediated by coordinated effects on the glutamine-GSH axis, and the HSP pathway, maintenance of mitochondrial metabolism and stimulus-secretion coupling essential for insulin release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 39537-23-0
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Appearance Solid
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Molecular Weight 217.22
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Formel C8H15N3O4
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Color White to off-white
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Synonyms
Alanyl-glutamine
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
miR-671-5p-enriched exosomes derived from human embryonic stem cells under hypoxia balance oxidative stress homeostasis and macrophage reprogramming to alleviate Legg-Calvé-Perthes disease by targeting NOX2. [Abstract]2026 Jun 15:179:116563. PMID: 41931957 -
Reprod Domest Anim
Glutamine Protects Porcine Granulosa Cell From Oxidative Stress-Induced Apoptosis by Inhibiting JNK Activation. [Abstract]2026 Feb;61(2):e70179. PMID: 41614661
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 50 mg/mL (230.18 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (460.36 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.6036 mL | 23.0181 mL | 46.0363 mL | 115.0907 mL |
| 5 mM | 0.9207 mL | 4.6036 mL | 9.2073 mL | 23.0181 mL | |
| 10 mM | 0.4604 mL | 2.3018 mL | 4.6036 mL | 11.5091 mL | |
| 15 mM | 0.3069 mL | 1.5345 mL | 3.0691 mL | 7.6727 mL | |
| 20 mM | 0.2302 mL | 1.1509 mL | 2.3018 mL | 5.7545 mL | |
| 25 mM | 0.1841 mL | 0.9207 mL | 1.8415 mL | 4.6036 mL | |
| 30 mM | 0.1535 mL | 0.7673 mL | 1.5345 mL | 3.8364 mL | |
| 40 mM | 0.1151 mL | 0.5755 mL | 1.1509 mL | 2.8773 mL | |
| 50 mM | 0.0921 mL | 0.4604 mL | 0.9207 mL | 2.3018 mL | |
| 60 mM | 0.0767 mL | 0.3836 mL | 0.7673 mL | 1.9182 mL | |
| 80 mM | 0.0575 mL | 0.2877 mL | 0.5755 mL | 1.4386 mL | |
| 100 mM | 0.0460 mL | 0.2302 mL | 0.4604 mL | 1.1509 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Alanyl-L-glutamine Related Classifications
HY-W014102 Related Classifications
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