Cat. No.: HY-W014102

L-Alanyl-L-glutamine

(Synonyms: Alanyl-glutamine)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations.

For research use only. We do not sell to patients.

Purity: 99.84%
CAS No.: 39537-23-0
Formula: C₈H₁₅N₃O₄
Molecular Weight:217.22

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

L-Alanyl-L-glutamine Chemical Structure

CAS No.: 39537-23-0

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Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations^[1].

All Endogenous Metabolite Isoforms :

In Vitro

L-Alanyl-L-glutamine (2 mM; 24 hours) partially or fully attenuates chronic insulin secretion, and IR-β and COX IV levels which are decreased when β-cells were exposed to macrophages following stimulation in vitro (IMMs)^[1].
L-Alanyl-L-glutamine -dependent β-cell protection mediated by coordinated effects on the glutamine-GSH axis, and the HSP pathway, maintenance of mitochondrial metabolism and stimulus-secretion coupling essential for insulin release^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 39537-23-0
Appearance Solid
Molecular Weight 217.22
Formula C₈H₁₅N₃O₄
Color White to off-white
Synonyms

Alanyl-glutamine
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Int Immunopharmacol

miR-671-5p-enriched exosomes derived from human embryonic stem cells under hypoxia balance oxidative stress homeostasis and macrophage reprogramming to alleviate Legg-Calvé-Perthes disease by targeting NOX2. [Abstract]

2026 Jun 15:179:116563. PMID: 41931957
Reprod Domest Anim

Glutamine Protects Porcine Granulosa Cell From Oxidative Stress-Induced Apoptosis by Inhibiting JNK Activation. [Abstract]

2026 Feb;61(2):e70179. PMID: 41614661

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (230.18 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.6036 mL

23.0181 mL

46.0363 mL

5 mM

0.9207 mL

4.6036 mL

9.2073 mL

10 mM

0.4604 mL

2.3018 mL

4.6036 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (460.36 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cruzat VF,et al. Alanyl-glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge. J Endocrinol. 2015 Mar;224(3):261-71. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	4.6036 mL	23.0181 mL	46.0363 mL	115.0907 mL
	5 mM	0.9207 mL	4.6036 mL	9.2073 mL	23.0181 mL
	10 mM	0.4604 mL	2.3018 mL	4.6036 mL	11.5091 mL
	15 mM	0.3069 mL	1.5345 mL	3.0691 mL	7.6727 mL
	20 mM	0.2302 mL	1.1509 mL	2.3018 mL	5.7545 mL
	25 mM	0.1841 mL	0.9207 mL	1.8415 mL	4.6036 mL
	30 mM	0.1535 mL	0.7673 mL	1.5345 mL	3.8364 mL
	40 mM	0.1151 mL	0.5755 mL	1.1509 mL	2.8773 mL
	50 mM	0.0921 mL	0.4604 mL	0.9207 mL	2.3018 mL
	60 mM	0.0767 mL	0.3836 mL	0.7673 mL	1.9182 mL
	80 mM	0.0575 mL	0.2877 mL	0.5755 mL	1.4386 mL
	100 mM	0.0460 mL	0.2302 mL	0.4604 mL	1.1509 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

L-Alanyl-L-glutamine

2 Cited Publications

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L-Alanyl-L-glutamine

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Publications Citing Use of MedChemExpress (MCE) L-Alanyl-L-glutamine

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

L-Alanyl-L-glutamine Related Classifications

HY-W014102 Related Classifications