1. Membrane Transporter/Ion Channel
    Apoptosis
  2. ATP Synthase
    Apoptosis
  3. Radicicol

Radicicol (Synonyms: Monorden)

Cat. No.: HY-N6769
Handling Instructions

Radicicol is an inhibitor of the ATPase/kinase with IC50 values of 1 μM, 100 μM and 400 μM, respectively for Hsp90, Topo VI and PDK3 . Radicicol inhibits a wide variety of tumor cell lines by targeting Hsp90, binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation . Radicicol is an antifungal antibiotic with antimalarial activity, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of fat mass and obesity-associated protein (FTO), exhibits a dose-dependent inhibition of FTO demethylation activity with an IC50 value of 16.04 µM.

For research use only. We do not sell to patients.

Radicicol Chemical Structure

Radicicol Chemical Structure

CAS No. : 12772-57-5

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Description

Radicicol is an inhibitor of the ATPase/kinase with IC50 values of 1 μM, 100 μM and 400 μM, respectively for Hsp90, Topo VI and PDK3 [1]. Radicicol inhibits a wide variety of tumor cell lines by targeting Hsp90, binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation [2]. Radicicol is an antifungal antibiotic with antimalarial activity, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB[2]. Radicicol is an inhibitor of fat mass and obesity-associated protein (FTO), exhibits a dose-dependent inhibition of FTO demethylation activity with an IC50 value of 16.04 µM[3].

IC50 & Target

IC50: of 1 μM (Hsp90), 100 μM (Topo VI) and 400 μM (PDK3)[1]

Molecular Weight

364.78

Formula

C₁₈H₁₇ClO₆

CAS No.

12772-57-5

SMILES

OC1=C2C(CC(/C=C/C=C\[[email protected]@H](O3)[[email protected]]3C[[email protected]@H](C)OC2=O)=O)=C(Cl)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Radicicol
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