1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. Radicicol

Radicicol (Synonyms: Monorden)

Cat. No.: HY-N6769
Handling Instructions

Radicicol is an inhibitor of Hsp90 with an IC50 value of 1 μM. Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation. Radicicol is an antifungal antibiotic with antimalarial activity, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB.

For research use only. We do not sell to patients.

Radicicol Chemical Structure

Radicicol Chemical Structure

CAS No. : 12772-57-5

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1 mg USD 280 In-stock
Estimated Time of Arrival: December 31
5 mg USD 835 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Radicicol is an inhibitor of Hsp90 with an IC50 value of 1 μM. Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation[1]. Radicicol is an antifungal antibiotic with antimalarial activity, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB[2].

IC50 & Target

HSP90

1 μM (IC50)

Molecular Weight

364.78

Formula

C₁₈H₁₇ClO₆

CAS No.

12772-57-5

SMILES

OC1=C2C(CC(/C=C/C=C\[[email protected]@H](O3)[[email protected]]3C[[email protected]@H](C)OC2=O)=O)=C(Cl)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

RadicicolMonordenHSPHeat shock proteinsInhibitorinhibitorinhibit

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Radicicol
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