1. Metabolic Enzyme/Protease
    Membrane Transporter/Ion Channel
    Autophagy
  2. HMG-CoA Reductase (HMGCR)
    Potassium Channel
    Autophagy
  3. (3S,5R)-Rosuvastatin

(3S,5R)-Rosuvastatin 

Cat. No.: HY-17504D
Handling Instructions

(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

For research use only. We do not sell to patients.

(3S,5R)-Rosuvastatin Chemical Structure

(3S,5R)-Rosuvastatin Chemical Structure

CAS No. : 1242184-42-4

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Description

(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3].

IC50 & Target

IC50: 11 nM (HMG-CoA)[1] and 195 nM (hERG)[2]

Molecular Weight

481.54

Formula

C₂₂H₂₈FN₃O₆S

CAS No.

1242184-42-4

SMILES

O=C(O)C[[email protected]@H](O)C[[email protected]@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(3S,5R)-RosuvastatinHMG-CoA Reductase (HMGCR)Potassium ChannelAutophagyKcsA(3S,5R)-enantiomerhERGHsp70LDL-CC-reactivetriglyceridesInhibitorinhibitorinhibit

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(3S,5R)-Rosuvastatin
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HY-17504D
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