1. Neuronal Signaling Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  2. Monoamine Oxidase HSP
  3. MAO A/HSP90-IN-1

MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research.

For research use only. We do not sell to patients.

MAO A/HSP90-IN-1 Chemical Structure

MAO A/HSP90-IN-1 Chemical Structure

CAS No. : 2927489-95-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All Monoamine Oxidase Isoform Specific Products:

View All HSP Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research[1].

IC50 & Target[1]

HSP90

0.019 μM (IC50)

MAO-A

1.77 μM (IC50)

In Vitro

MAO A/HSP90-IN-1 (4-b) (0.1 μM-3 μM, 24h) reduces the proliferation of GBM cells via inhibiting MAO A and HSP90[1].
MAO A/HSP90-IN-1 (0.1 μM-3 μM, 24h) shows IC50 0.73 μM in GL26, 1.68 μM in U251S, and 0.84 μM in U251R[1].
MAO A/HSP90-IN-1 (0μM, 0.35μM, 0.7μM, 1.4μM, 24h) inhibits IFN-γ induced PD-L1 expression concentration-dependently in GL26 mouse GBM cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U87MG, U373MG, LN229, A172, T98G, P1S, P3, and P3R human GBM cells
Concentration: 50 μM
Incubation Time: 72 h
Result: Inhibited cell growth in GBM cell lines with an IC50 ratio was around 1 except A172 cell.

Western Blot Analysis[1]

Cell Line: GL26, U251R cells
Concentration: 3μM, 1μM, 0.3μM, 0.1μM
Incubation Time: 24 h
Result: Decreased the protein expression of HER2 and phospho-Akt in GL26 and U251R cell lines.
In Vivo

MAO A/HSP90-IN-1 (4-b) (25 mg/kg for intraperitoneal injection, once a day) shows significantly decreased tumor growth in GL26 GBM mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GL26 GBM mouse model[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Decreased tumor growth inhibition (TGI%) was 63.2% compared to vehicle group.
Molecular Weight

444.95

Formula

C24H29ClN2O4

CAS No.
SMILES

CN(C1=CC(Cl)=C(C=C1)OCCCN(CC#C)C)C(C2=C(C=C(C(C(C)C)=C2)O)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MAO A/HSP90-IN-1
Cat. No.:
HY-155577
Quantity:
MCE Japan Authorized Agent: