1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. PKI(5-24)

PKI(5-24) 

Cat. No.: HY-P0222 Purity: 98.95%
Handling Instructions

PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PKI(5-24) Chemical Structure

PKI(5-24) Chemical Structure

CAS No. : 99534-03-9

Size Price Stock Quantity
5 mg USD 290 In-stock
Estimated Time of Arrival: December 31
10 mg USD 490 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PKI(5-24):

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Description

PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].

In Vitro

PKI(5-24) is a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein[1].
PKI(5-24) inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency than that of wild type, with Ki values of 42 μΜ and 160 μΜ, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2222.38

Formula

C₉₄H₁₄₈N₃₂O₃₁

CAS No.
Sequence

Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp

Sequence Shortening

TTYADFIASGRTGRRNAIHD

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (15.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4500 mL 2.2498 mL 4.4997 mL
5 mM 0.0900 mL 0.4500 mL 0.8999 mL
10 mM 0.0450 mL 0.2250 mL 0.4500 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

PKI(5-24)PKAProtein kinase AmutantsensitivitycompetitiveskeletalmuscleInhibitorinhibitorinhibit

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Product Name:
PKI(5-24)
Cat. No.:
HY-P0222
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