1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. PKI(5-24) TFA

PKI(5-24) TFA 

Cat. No.: HY-P0222A
Handling Instructions

PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PKI(5-24) TFA Chemical Structure

PKI(5-24) TFA Chemical Structure

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Description

PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].

In Vitro

PKI(5-24) TFA is a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein[1].
PKI(5-24) TFA inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency than that of wild type, with Ki values of 42 μΜ and 160 μΜ, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2336.40

Formula

C₉₄H₁₄₈N₃₂O₃₁.C₂HF₃O₂

Sequence

Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp

Sequence Shortening

TTYADFIASGRTGRRNAIHD

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PKI(5-24)PKAProtein kinase AmutantsensitivitycompetitiveskeletalmuscleInhibitorinhibitorinhibit

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PKI(5-24) TFA
Cat. No.:
HY-P0222A
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