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Cat. No.: HY-19399B

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Iroxanadine sulfate

(Synonyms: (-)-BRX 005 sulfate; (-)-BRX 235 sulfate)

Iroxanadine (BRX 005) sulfate is a vasculoprotector. Iroxanadine is a p38 kinase and HSP protein dual activator. Iroxanadine sulfate has the potential for atherosclerosis and vascular diseases research.

For research use only. We do not sell to patients.

CAS No.: 276690-61-0
Formula: C₁₄H₂₂N₄O₅S
Molecular Weight:358.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Iroxanadine sulfate Chemical Structure

CAS No.: 276690-61-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All p38 MAPK Isoforms :

All HSP Isoforms :

In Vitro

Iroxanadine sulfate (0.1-1 μM) to culture medium prior to hypoxia or at start of reoxygenation significantly reduced the caspase-dependent apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 276690-61-0
Molecular Weight 358.41
Formula C₁₄H₂₂N₄O₅S
SMILES

O=S(O)(O)=O.C1(NC(C2=CN=CC=C2)=NOC1)CN3CCCCC3
Synonyms

(-)-BRX 005 sulfate; (-)-BRX 235 sulfate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Denes L, et al. Reverse regulation of endothelial cells and myointimal hyperplasia on cell proliferation by a heatshock protein-coinducer after hypoxia. Stroke. 2008 Mar;39(3):1022-4. [Content Brief]

[2]. Kabakov AE, et al. Pharmacological attenuation of apoptosis in reoxygenated endothelial cells. Cell Mol Life Sci. 2004 Dec;61(24):3076-86. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Iroxanadine sulfate

All p38 MAPK Isoforms

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Iroxanadine sulfate Related Classifications

HY-19399B Related Classifications