(3R,5R)-Rosuvastatin
(3R,5R)-Rosuvastatin is a hERG potassium channel blocker and HMG-CoA reductase inhibitor that prolongs the action potential duration and QT interval by accelerating channel inactivation, impairing channel folding, reducing hERG mRNA transcription, and promoting the degradation of mature and immature hERG channels. (3R,5R)-Rosuvastatin can be used for research on long QT syndrome.
For research use only. We do not sell to patients.
- CAS No.: 1094100-06-7
- Formula: C22H28FN3O6S
- Molecular Weight:481.54
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
(3R,5R)-Rosuvastatin is a stereoisomer of Rosuvastatin and an HMG-CoA reductase inhibitor with lower activity than the clinically used (3R,5S) configuration, and it is used in stereochemistry-related studies[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1094100-06-7
-
Molecular Weight 481.54
-
Formula C22H28FN3O6S
-
SMILES
O=C(O)C[C@H](O)C[C@@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Molecular pharmaceutics. 2019 Apr 01;16(4):1477-1488. [Content Brief]
[2]. Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. Journal of pharmaceutical sciences. 2012 Feb;101(2):868-78. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(3R,5R)-Rosuvastatin Related Classifications
HY-17504C Related Classifications
Powered by Bioz
Keywords
- (3R,5R)-Rosuvastatin
- 1094100-06-7
- HMG-CoA Reductase (HMGCR)
- Potassium Channel
- long QT syndrome
- HMG-CoA reductase inhibitor
- lysosomal degradation
- human induced pluripotent stem cell-derived cardiomyocytes
- unfolded protein response pathway
- ATF6
- proteasomal degradation
- Hsp70
- Sp1 transcription factor
- hERG potassium channel blocker
- Inhibitor
- inhibitor
- inhibit