1. Metabolic Enzyme/Protease
  2. HMG-CoA Reductase (HMGCR)
  3. HMG499

HMG499 

Cat. No.: HY-114316
Handling Instructions

HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis.

For research use only. We do not sell to patients.

HMG499 Chemical Structure

HMG499 Chemical Structure

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Description

HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis[1].

IC50 & Target

IC50: 0.41 μM (HMG-CoA reductase)[1]

Molecular Weight

498.78

Formula

C₃₃H₅₄O₃

SMILES

O[[email protected]](C1(C)C)CC[[email protected]@]2(C)C1=C[[email protected]](O)C3C2CC[[email protected]@]4(C)C3CC[[email protected]@H]4[[email protected]@H](CCCC(CC=C)(O)CC=C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The dilution calculator equation

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Product Name:
HMG499
Cat. No.:
HY-114316
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