1094100-06-7
Chemical Structure
(3R,5R)-Rosuvastatin
- CAS. Nr.: 1094100-06-7
- Formula:C22H28FN3O6S
- Molecular Weight:481.54
IUPAC Name: (3R,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid
InChIKey: BPRHUIZQVSMCRT-YXWZHEERSA-N
SMILES: O=C(O)C[C@H](O)C[C@@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2
Biological Activity: (3R,5R)-Rosuvastatin is a hERG potassium channel blocker and HMG-CoA reductase inhibitor that prolongs the action potential duration and QT interval by accelerating channel inactivation, impairing channel folding, reducing hERG mRNA transcription, and promoting the degradation of mature and immature hERG channels. (3R,5R)-Rosuvastatin can be used for research on long QT syndrome[1][2].
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(3R,5R)-Rosuvastatin | (3R,5R)-Rosuvastatin is a hERG potassium channel blocker and HMG-CoA reductase inhibitor that prolongs the action potential duration and QT interval by accelerating channel inactivation, impairing channel folding, reducing hERG mRNA transcription, and promoting the degradation of mature and immature hERG channels. (3R,5R)-Rosuvastatin can be used for research on long QT syndrome. | |||||||||||||||||||||
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References
- [1]. Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Molecular pharmaceutics. 2019 Apr 01;16(4):1477-1488. [Content Brief]
- [2]. Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. Journal of pharmaceutical sciences. 2012 Feb;101(2):868-78. [Content Brief]
