1. Metabolic Enzyme/Protease
  2. HMG-CoA Reductase (HMGCR)

Monacolin J (Synonyms: Antibiotic MB 530A; Lovastatin diol lactone)

Cat. No.: HY-104051
Handling Instructions

Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

For research use only. We do not sell to patients.

Monacolin J Chemical Structure

Monacolin J Chemical Structure

CAS No. : 79952-42-4

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

IC50 & Target

HMG-CoA reductase[1]

In Vitro

Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. Na salt of Monacolin J causes 50% inhibition on reductase at 1.2 μg/mL[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1209 mL 15.6045 mL 31.2090 mL
5 mM 0.6242 mL 3.1209 mL 6.2418 mL
10 mM 0.3121 mL 1.5605 mL 3.1209 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

320.42

Formula

C₁₉H₂₈O₄

CAS No.

79952-42-4

SMILES

O=C1C[[email protected]](O)C[[email protected]@H](CC[[email protected]]2[[email protected]@H](C)C=CC3=C[[email protected]](C)C[[email protected]](O)[[email protected]]23[H])O1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Monacolin J
Cat. No.:
HY-104051
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Monacolin J

Cat. No.: HY-104051