ICG-carboxylic acid
Based on 1 publication(s) in Google Scholar
ICG-carboxylic acid is near-infrared (NIR) fluorescent probe. ICG is a fluorescent dye used in medical diagnostics. ICG has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue (Ex/Em = 785/810 nm).
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 181934-09-8
- Formula: C45H50N2O5S
- Molecular Weight:730.95
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ICG-carboxylic acid
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Biological Activity
Guidelines (The following is our recommended protocol; this protocol serves merely as a guideline and should be modified according to your specific needs)[3]
1. Add 1 mg of ICG-carboxylic acid to 10 mL of water containing 100 mg of the aluminum-rich polysaccharide “SpaTA”; subsequently, mix with 50 mg of EDC/NHS and allow the reaction to proceed catalytically at room temperature for 6 hours.
2. Transfer the solution into a micro-dialysis bag, then purify it using 10 mM PBS.
3. Replace the dialysis buffer every 4 hours, for a total of three changes.
4. Determine the Relative Fluorescence Units (RFU) of the ICG-loaded SpaTA and the ICG standard using fluorescence spectrophotometry, with an excitation wavelength of 805 nm and an emission wavelength of 835 nm.
5. The formula for calculating the ICG Loading Rate (LR) is as follows:
LR% = RFUSample / RFUStandard.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
810
785
Chemical Information
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CAS No. 181934-09-8
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Appearance Solid
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Molecular Weight 730.95
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Formula C45H50N2O5S
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Color Brown to black
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SMILES
CC1(C)C(/C=C/C=C/C=C/C=C2C(C)(C)C(C(C=CC=C3)=C3C=C4)=C4N\2CCCCCC([O-])=O)=[N+](CCCCS(=O)(O)=O)C5=C1C6=CC=CC=C6C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
Targeted extracellular vesicle-photoimmunotherapy remodels stromal-immune microenvironment to boost chemo-immunotherapy in preclinical models. [Abstract]2026 Jun 3:102843. PMID: 42235518
Solvent & Solubility
DMSO : 50 mg/mL (68.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Taylor JS, et al. Combined application of Indocyanine green (ICG) and laser lead to targeted tumor cell destruction. J Pediatr Surg. 2018;53(12):2475-2479. [Content Brief]
[2]. Mačianskienė R, et al. Spectral characteristics of voltage-sensitive indocyanine green fluorescence in the heart. Sci Rep. 2017;7(1):7983. Published 2017 Aug 11. [Content Brief]
[3]. Wu YZ, et al. From Ancient Medicine to Targeted Nanocarrier: A Sparganii Rhizoma-Derived Nanoparticle for Diagnostic Imaging and Endocrine Therapy in Cancer. ACS Appl Bio Mater. 2020 Apr 20;3(4):2028-2039. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3681 mL | 6.8404 mL | 13.6808 mL | 34.2021 mL |
| 5 mM | 0.2736 mL | 1.3681 mL | 2.7362 mL | 6.8404 mL | |
| 10 mM | 0.1368 mL | 0.6840 mL | 1.3681 mL | 3.4202 mL | |
| 15 mM | 0.0912 mL | 0.4560 mL | 0.9121 mL | 2.2801 mL | |
| 20 mM | 0.0684 mL | 0.3420 mL | 0.6840 mL | 1.7101 mL | |
| 25 mM | 0.0547 mL | 0.2736 mL | 0.5472 mL | 1.3681 mL | |
| 30 mM | 0.0456 mL | 0.2280 mL | 0.4560 mL | 1.1401 mL | |
| 40 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8551 mL | |
| 50 mM | 0.0274 mL | 0.1368 mL | 0.2736 mL | 0.6840 mL | |
| 60 mM | 0.0228 mL | 0.1140 mL | 0.2280 mL | 0.5700 mL |
ICG-carboxylic acid Related Classifications
HY-W088089 Related Classifications
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