H1PVAT
Based on 1 Customer Validation
H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation.
For research use only. We do not sell to patients.
- Purity: 96.40%
- CAS No.: 351438-49-8
- Formula: C19H14F3N5OS
- Molecular Weight:417.42
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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High-Throughput Bioactive Compound Library
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Biological Activity
EC50: 10 nM (PV-1), 26 nM (PV-2), 218 nM (PV-3)[1]
H1PVAT (10-218 nM; 24-48 h) inhibits poliovirus strain Sabin replication in a dose-dependent manner, with EC50s of 10 nM (PV-1), 26 nM (PV-2) and 218 nM (PV-3), respectively[1].
H1PVAT (30 min prior to or 1 h after PV-1 infection; 7 h) inhibits an early stage of viral replication , and only H1PVAT is administered prior to infection results reduction (>99.9%) in intracellular viral RNA levels[1].
H1PVAT (50 μM; 2 min) protects PV against heat inactivation with the 50% thermal inactivation temperature increased to 52.6 °C and 50.8 °C, which suggests a direct interaction between the viral capsid and H1PVAT[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 351438-49-8
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Appearance Solid
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Molecular Weight 417.42
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Formula C19H14F3N5OS
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Color White to off-white
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SMILES
O=C(C1=NN2C(C(F)(F)F)CC(C3=CC=CS3)NC2=C1)NC4=CC=C(C#N)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (59.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3957 mL | 11.9783 mL | 23.9567 mL | 59.8917 mL |
| 5 mM | 0.4791 mL | 2.3957 mL | 4.7913 mL | 11.9783 mL | |
| 10 mM | 0.2396 mL | 1.1978 mL | 2.3957 mL | 5.9892 mL | |
| 15 mM | 0.1597 mL | 0.7986 mL | 1.5971 mL | 3.9928 mL | |
| 20 mM | 0.1198 mL | 0.5989 mL | 1.1978 mL | 2.9946 mL | |
| 25 mM | 0.0958 mL | 0.4791 mL | 0.9583 mL | 2.3957 mL | |
| 30 mM | 0.0799 mL | 0.3993 mL | 0.7986 mL | 1.9964 mL | |
| 40 mM | 0.0599 mL | 0.2995 mL | 0.5989 mL | 1.4973 mL | |
| 50 mM | 0.0479 mL | 0.2396 mL | 0.4791 mL | 1.1978 mL |
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