1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. Arimoclomol maleate

Arimoclomol maleate (Synonyms: BRX-220)

Cat. No.: HY-106443A
Handling Instructions

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP).

For research use only. We do not sell to patients.

Arimoclomol maleate Chemical Structure

Arimoclomol maleate Chemical Structure

CAS No. : 289893-26-1

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Publications Citing Use of MCE Arimoclomol maleate

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Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP).

IC50 & Target



In Vivo

The HSP coinducer Arimoclomol (BRX-220), administered for 5 d, has a protective effect against CCK-induced acute pancreatitis. Repeated CCK treatment results in the typical laboratory and morphological changes of experimentally induced pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased in the animals treated with Arimoclomol [1]. Arimoclomol is a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease[2].

Clinical Trial
Molecular Weight







Cl/C(C(C=CC=1)=CN1=O)=N\OC[[email protected]](O)CN2CCCCC2.OC(/C=C\C(O)=O)=O


Room temperature in continental US; may vary elsewhere


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

Male Wistar rats weighing 240-270 g are used. The animals are kept at a constant room temperature of 25°C with a 12 h light-dark cycle, and are allowed free access to water and standard laboratory chow. The rats are fasted 18 h before the end of the experiment. In group B (n=6), 20 mg/kg Arimoclomol (BRX-220) is administered intragastrically, followed by 75 μg/kg CCK subcutaneously three times, after 1, 3, and 5 h. This whole procedure is repeated for 5 d. The animals in group AB (n=6) receive physiological saline intragastrically instead of Arimoclomol, but otherwise the protocol is the same as in group B. The animals are sacrificed by exsanguination through the abdominal aorta 12 h after the last CCK injection. Three untreated rats (A) are killed for HSP60 and 72 determinations. The pancreas is quickly removed, cleaned from fat and lymph nodes, weighed, and frozen at -70°C until use[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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