Arimoclomol maleate
Based on 7 publication(s) in Google Scholar
Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol maleate can be used for the study of Niemann–Pick disease type C.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 289893-26-1
- Formula: C18H24ClN3O7
- Molecular Weight:429.85
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Arimoclomol maleate
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Customer Validation & Images
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WB
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WB
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ELISA
Biological Activity
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HSP |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats weighing 240 to 270 g[1]
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Dosage:20 mg/kg
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Administration:Administered intragastrically, for 5 days
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Result:Had a protective effect against CCK-induced acute pancreatitis.
Chemical Information
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CAS No. 289893-26-1
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Appearance Solid
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Molecular Weight 429.85
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Formula C18H24ClN3O7
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Color White to light yellow
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SMILES
Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2.OC(/C=C\C(O)=O)=O
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Synonyms
BRX-220
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion. [Abstract]2026 May 2;23(1):206. PMID: 42069589 -
J Neurochem
Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP-43 Proteinopathy. [Abstract]2026 Jun;170(6):e70493. PMID: 42283221 -
Exp Eye Res
4-HNE induces proinflammatory cytokines of human retinal pigment epithelial cells by promoting extracellular efflux of HSP70. [Abstract]2019 Nov:188:107792. PMID: 31499034
Arimoclomol maleate purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2019 Nov:188:107792. [Abstract]
Western blot was used to detect the expression of HSP70 in ARPE-19 cells stimulated by Arimoclomol maleate (10 μM) for 24 h.
Arimoclomol maleate purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2019 Nov:188:107792. [Abstract]
ARPE-19 cells were simultaneously treated with 4-HNE and Arimoclomol (10 μM) for 24 h, then IL-1β levels in supernatant of ARPE-19 cells were detected by corresponding ELISA kit.
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Int J Mol Sci
Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function. [Abstract]2024 May 16;25(10):5417. PMID: 38791456
Arimoclomol maleate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 May 16;25(10):5417. [Abstract]
Representative western blotting showing the effect of Arimoclomol maleate (Ari: 300 μM) treatments on protein expression in PS1 (PS1KO) and PS2 KO (PS2KO) mouse embryonic fibroblasts (MEFs).
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Solvent & Solubility
DMSO : 250 mg/mL (581.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (232.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (232.64 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [Content Brief]
[2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 2.3264 mL | 11.6320 mL | 23.2639 mL | 58.1598 mL |
| 5 mM | 0.4653 mL | 2.3264 mL | 4.6528 mL | 11.6320 mL | |
| 10 mM | 0.2326 mL | 1.1632 mL | 2.3264 mL | 5.8160 mL | |
| 15 mM | 0.1551 mL | 0.7755 mL | 1.5509 mL | 3.8773 mL | |
| 20 mM | 0.1163 mL | 0.5816 mL | 1.1632 mL | 2.9080 mL | |
| 25 mM | 0.0931 mL | 0.4653 mL | 0.9306 mL | 2.3264 mL | |
| 30 mM | 0.0775 mL | 0.3877 mL | 0.7755 mL | 1.9387 mL | |
| 40 mM | 0.0582 mL | 0.2908 mL | 0.5816 mL | 1.4540 mL | |
| 50 mM | 0.0465 mL | 0.2326 mL | 0.4653 mL | 1.1632 mL | |
| 60 mM | 0.0388 mL | 0.1939 mL | 0.3877 mL | 0.9693 mL | |
| 80 mM | 0.0291 mL | 0.1454 mL | 0.2908 mL | 0.7270 mL | |
| 100 mM | 0.0233 mL | 0.1163 mL | 0.2326 mL | 0.5816 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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