1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. Arimoclomol maleate

Arimoclomol maleate (Synonyms: BRX-220)

Cat. No.: HY-106443A Purity: 99.96%
Handling Instructions

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.

For research use only. We do not sell to patients.

Arimoclomol maleate Chemical Structure

Arimoclomol maleate Chemical Structure

CAS No. : 289893-26-1

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
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10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].

IC50 & Target[1]

HSP

 

In Vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 240 to 270 g[1]
Dosage: 20 mg/kg
Administration: Administered intragastrically, for 5 days
Result: Had a protective effect against CCK-induced acute pancreatitis.
Clinical Trial
Molecular Weight

429.85

Formula

C₁₈H₂₄ClN₃O₇

CAS No.

289893-26-1

SMILES

Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[[email protected]](O)CN2CCCCC2.OC(/C=C\C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (581.60 mM; Need ultrasonic)

H2O : 100 mg/mL (232.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3264 mL 11.6320 mL 23.2639 mL
5 mM 0.4653 mL 2.3264 mL 4.6528 mL
10 mM 0.2326 mL 1.1632 mL 2.3264 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (232.64 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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Keywords:

ArimoclomolBRX-220BRX220BRX 220HSPHeat shock proteinsco-inducermotorneuronsproteinaggregationclearancemisfoldedassembliesproteasomeubiquitinsystemInhibitorinhibitorinhibit

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Product Name:
Arimoclomol maleate
Cat. No.:
HY-106443A
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