1. GPCR/G Protein
  2. Glucagon Receptor
  3. Semaglutide

Semaglutide 

Cat. No.: HY-114118 Purity: 99.84%
Handling Instructions

Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide has the potential for type 2 diabetes treatment.

For research use only. We do not sell to patients.

Semaglutide Chemical Structure

Semaglutide Chemical Structure

CAS No. : 910463-68-2

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500 μg USD 160 In-stock
Estimated Time of Arrival: December 31
1 mg USD 260 In-stock
Estimated Time of Arrival: December 31
5 mg USD 910 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide has the potential for type 2 diabetes treatment.

IC50 & Target

GLP-1 receptor[1].

In Vitro

Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM[1]. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs[1]. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to NN-2211 in most parameters[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

4113.64

CAS No.

910463-68-2

SMILES

[Semaglutide]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (12.15 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (8.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2431 mL 1.2155 mL 2.4309 mL
5 mM 0.0486 mL 0.2431 mL 0.4862 mL
10 mM 0.0243 mL 0.1215 mL 0.2431 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2]

Mice[2]
Male C57BL/6 mice 10 weeks old (20-25 g) are used throughout the study. Mice are randomized divided into six groups (n=12 per group) (i) control group treated with saline alone; (ii) NN-2211 group treated with saline and NN-2211 (25 nmol/kg ip. once daily for 7 days); (iii) Semaglutide group treated with saline and Semaglutide (25 nmol/kg ip. once daily for 7 days), (iv) MPTP group treated with MPTP alone (once daily 20 mg/kg ip. for 7 days); (v) MPTP (once daily 20 mg/kg ip. for 7 days) followed immediately by NN-2211 treated group (25 nmol/kg ip. once daily for 7 days). (vi) MPTP (20 mg/kg ip. once daily for 7 days) followed immediately by Semaglutide treated group (25 nmol/kg ip. Once daily for 7 days). At the end of drug treatments, measure the behavioral changes, neuronal damage, inflammatory markers, and other biomarkers[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.84%

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Keywords:

SemaglutideGlucagon ReceptorGCGRInhibitorinhibitorinhibit

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Product Name:
Semaglutide
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HY-114118
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